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3D Print Glycated Hemoglobin HbA1c

Use this 3D printed protein model of the HbA1c, the protein marker that helps identify diabetes onset and tested for in the HbA1c (“A1c”) blood test. Use this 3D model to explain the dangers of high blood sugar or a reminder to monitor your blood sugar. Model available in multiple sizes and material finishes!
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CRISPR Cpf1, Biologic Models,

3D Print CRISPR Cpf1

Configure and 3D Print in a variety of materials and sizes a hand-held model of CRISPR Cpf1. This model of Cpf1 can be 3D printed in a variety of materials and sizes. Seen here, Cpf1 is colored blue, DNA colors yellow and green, and guide RNA colored Red. Below is a photo of both our CRISPR Cpf1 and Cas9 models.

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Hemoglobin, Hb, 1HHO, Biologic Models

Oxygenated Hemoglobin Hb

Protein Description

Hemoglobin; abbreviated Hb or Hgb, is the iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates as well as the tissues of some invertebrates. Hemoglobin in the blood carries oxygen from the lungs or gills to the rest of the body (i.e. the tissues). There it releases the oxygen to permit aerobic respiration to provide energy to power the functions of the organism in the process called metabolism. A healthy individual has “12 to 16” grams of hemoglobin in every 100 ml of blood.

In 1825 J. F. Engelhard discovered that the ratio of iron to protein is identical in the hemoglobins of several species. This protein model was created from PDB ID: 1HHO

Media Gallery

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Model Description

This is a 3D print of Oxygenated Hemoglobin (Hb), created from PDB ID: 1HHO. The globulin chains (2x A,B) of this model are colored white, HEME groups red, and Oxygen Molecules Blue. This model also visualizes the location of Glu6 residue (medium Grey) of both chain Bs. This amino acid is known to mutate in Sickle Cell Anemia causing hemoglobin molecules to stick together at Phe85 and Leu88 (Light Grey).

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Ebola, Virus, Biologic Models

3D Print Ebola Virus Ectodomain

Protein Description

“Ebolavirus (EBOV) is a highly virulent pathogen capable of causing a severe hemorrhagic fever with 50–90% lethality. The EBOV glycoprotein (GP) is the only virally expressed protein on the virion surface and is critical for attachment to host cells and catalysis of membrane fusion. Hence, the EBOV GP is a critical component of vaccines as well as a target of neutralizing antibodies and inhibitors of attachment and fusion. The crystal structure of the Zaire ebolavirus GP in its trimeric, prefusion conformation (3 GP1 plus 3 GP2) in complex with a neutralizing antibody fragment, derived from a human survivor of the 1995 Kikwit outbreak, was recently determined.

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This is the first near-complete structure of any filovirus glycoprotein. The overall molecular architecture of the Zaire ebolavirus GP and its role in viral entry and membrane fusion are discussed in this article.”  — NCBI Citation

3D Animation

Ebola Virus Ectodomain in complex with Human Antibodies from Biologic Discovery on Vimeo.

The ebola virus has a natural enemy, the human immune system. Those lucky enough to survey this deadly virus produce an antibody which identifies the virus for destruction. The above animation shows these antibodies attached to the ectodomains of the virus.

Model Description

This is a 3D print of x-ray crystallography datasets PDB IDs: 3CSY, 2EBO  The protein surface color coding is defined by the glycoprotein’s Hydrophobicity. To delineate the different chains, we have colored the GP2-Glycoprotein-plasma membrane shades of green. The model can be printed in a variety of materials and sizes.

3D Print Ebola Virus Ectodomain

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Nucleosome, Biologic Models, 3C1B

Nucleosome

Protein Description 3C1B

Here we present crystal structures of nucleosomes reconstituted with methylated histones and investigate the folding behavior of resulting arrays. We demonstrate that dimethylation of histone H3 at lysine residue 79 locally alters the nucleosomal surface, whereas trimethylation of H4 at lysine residue 20 affects the higher-order structure. 

Model Description

This is a 3D printed model of Nucleosome. A nucleosome is a structural unit of a eukaryotic chromosome, consisting of a length of DNA coiled around a core of histones. The core is made up of 8 histone proteins colored purple according to their bFactor, warmest=pink, coolest=blue. The coiled DNA strand is colored from N to C Terminal blue to red. This allows us to see the anti-parallel winding of one DNA strand to another.

3D Print Nucleosome

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