This is a model of human insulin in its stable macro-molecule hexamer form. It is colored by the protein’s bFactor or atomic temperature. Chains A and C are stained yellow, and Chains B and D are stained lite orange. The core of the macromolecule shows the stable, cool binding region of each monomer, an important characteristic […]
CRISPR Cas9 printed in full-color sandstone colored purple according to the protein’s bFactor, it’s propensity for movement. RNA is colored red, DNA colored Yellow and Green. Protein Description “The RNA-guided DNA endonuclease CRISPR Cas9 cleaves double-stranded DNA targets with a protospacer adjacent motif (PAM) and complementarity to the guide RNA. Recently, we harnessed Staphylococcus aureus […]
3D print of Pembrolizumab (KEYTRUDA) bound to PD-1. Model available in multiple materials and sizes. “Pembrolizumab (formerly MK-3475and lambrolizumab, trade name Keytruda) is a humanized antibodyused in cancer immunotherapy. It destroys a protective mechanism on cancer cells, and allows the immune system to destroy those cancer cells. It targets the programmed cell death 1(PD-1) receptor. The drug was initially used in treating metastatic melanoma.” Protein […]
Model Description 3D print of T4 Phage bound to single stranded DNA. Multiple materials and sizes available. (more…)
Happy Holidays from Biologic Discovery! 3D Print of a CENP-A-histone H4 complex bound to the Holiday Junction. (more…)
3D Print of Phosphoinositide 3-Kinase (PI3K) denoting common mutation sites (E545, H1047) that result in an oncogenic enzyme. This model was created from PDB dataset: 5DXT and visualizes the PI3K inhibitor GDC-0326. Protein Description PI3K are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in […]
This is a visualization of PARP1 bound by Zejula, the first in class drug for women with recurrent ovarian cancer, regardless of BRCA mutation. Zejula is an oral medication taken once daily. Protein Description Poly(ADP-ribose) polymerase 1 (PARP1) is an enzyme that in humans is encoded by the PARP1 gene. It is one of the PARP family of enzymes. PARP1 […]
Trial Room Exhibits Occasionally, attorneys will contact me and request media to be used in trials or witness depositions. Attorneys understand that medical procedures and personal injuries are difficult to explain verbally. Testimony relies on verbal explanations of things that require knowledge that most jurors simply don’t have. They often request 3D animations to simplify how trauma […]
Hemoglobin A1c Blood Test The Hemoglobin A1c (HbA1c) blood test is given to nearly every single person living with diabetes and anyone at risk of developing diabetes. It is the preferred diagnostic tool used around the world to measure a patient’s long-term self-management of diabetes. Hundreds of millions of people each year will receive this test. Yet, despite […]
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This is a model of the pharmaceutical drug Humalog, insulin lispro, in its stable macro-molecule hexamer form. It is colored by the protein’s bFactor, or atomic temperature. Chains A and C are stained yellow, and Chains B and D are stained dark orange-red. The core of the macromolecule shows the stable, cool binding region of each monomer, an […]
This is a model of the pharmaceutical drug Tresiba, insulin degludec, in its stable macro-molecule hexamer form. Tresiba is a fascinating drug, engineered to create long, marcro-molecular filaments that get stored in fat. Attached to each hexamer are 6 hydrocarbon chains (blue-cyan sticks). They act like tails reaching out to a neighbor hexamer to bind. […]
This is a model of the pharmaceutical drug Novolog, insulin aspart, in its stable macro-molecule hexamer form. It is colored by the protein’s bFactor, or atomic temperature. Chains A and C are stained yellow, and Chains B and D are stained dark orange-red. The core of the macromolecule shows the stable, cool binding region of each monomer, an […]
Model Description This is a volumetric reconstruction of genome editing system, CRISPR Cpf1. It can be 3D printed in a variety of materials and sizes. Protein Description Clustered Regularly Interspaced Short Palindromic Repeats from Prevotella and Francisella CRISPR/Cpf1 is a DNA-editing technology analogous to the CRISPR Cas9 system, characterized in 2015 by Feng Zhang‘s group from the Broad Institute and MIT. […]
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