The SARS-CoV-2 Spike Glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. Biologic Models designed this 3D printed protein model of the SARS-CoV-2 Receptor Binding Domain Delta Plus Mutant 6VXX helps research scientists track viral mutations.
SARS-CoV-2 Receptor Binding Domain Delta Plus Mutant 6VXX
The Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein (PDB ID: 6VXX seen below) is the apex of the Spike that reaches out and binds ACE2 Receptors. It is characterized by a Binding motif (dark green) that localizes most of the SARS-CoV-2 residues that interact with ACE2 residues. Targeting these residues with Neutralizing Antibodies is a proven strategy to inhibit viral infection. Furthermore, mutations to these residues may dramatically change how the virus interacts with ACE2 or worse, evade immune responses.
Biologic Explorer: 6VXX-RBD Delta Plus Mutant