Recent projects completed by Biologic Models
Sugar attaches to hemoglobin (Hb) and changes the protein's shape, impairing its function. Learn more about the dangers of high blood sugar and the importance of knowing your HbA1c test scores using 3D reproductions of Glycated Hemoglobin (HbA1c).
Recently, Cornell University commissioned us to create 3D printed models of PIP4K II Alpha and Beta for the purpose of demonstrating PIP4K dimerization.
This is a 3D print of CRISPR Ca9 is created in full-color sandstone. The model depicts CRISPR (purple) bound to its guide RNA (red) while editing its Target DNA (yellow and green). The subtle color variations in the CRISPR are associated with its bFactor, or atomic temperature. The darker the color, the less the protein moves with a cooler atomic temperature.
This molecular model kit contains a 3D printed protein model of CRISPR Cpf1, model base, and Augmented Reality App. This model is printed in full-color sandstone. CRISPR Cpf1 domains are colored blue, DNA colors yellow and green, and guide RNA colored Red. Download the free Biologic Explorer App and explore CRISPR's internal atomic structures.
Model Description 3D Print of Antibody-Drug Conjugate visualized as a volumetric surface and colored blue by the protein's bFactor. Attached to the surface of the antibody are small cytotoxic molecule drugs.
This is a 3D print of the Insulin Receptor in complex with Insulin. This model is generated from PDB IDs: 5KQV and 2MFR. It is color-coded to denote the dimer configuration on the plasma membrane. Customize and 3D print this Biologic Model of an Insulin Receptor bound by Insulin.
This is a 3D printed model of Nucleosome. The core is made up of 8 histone proteins colored purple according to their bFactor, warmest=pink, coolest=blue. The coiled DNA strand is colored from N to C Terminal blue to red. This allows us to see the anti-parallel winding of one DNA strand to another. Created from PDB ID: 3C1B
Customize a 3D Printed Protein Model of Oxygenated Hemoglobin Hb, visualized as a volumetric surface, available in multiple sizes and materials.
This 3D printed protein model of Asparaginase created from PDB ID: 5MQ5. Asparaginase exists as both a monomer (single Asparaginase) and dimer (two bound Asparaginase). The monomer is colored green by the protein's bFactor, yellow-green the hottest and blue-green the coolest. Mutation N24S is colored orange-red.
ETH Zurich researchers make a major breakthrough in our understanding of the glycosylation process after crystallization of the Oligosaccharyltransferase (OST) Complex, the protein that attaches sugar chains. Biologic Models visualizes this dataset as a 3D Printed Protein Mode
This 3D print of MT-3724 demonstrates a unique mechanism of action of this immunotoxin. MT-3724 is a new type of immunotherapy developed by Molecular Templates.
This is a 3D print of a humanized monoclonal IgG4 antibody used in multiple types of cancer treatments. Models available in multiple materials and sizes.
EGFR is an important protein for a variety of different types of oncology. It is important for the development of mammary glands. It's ligands ( TGF-α, and heregulin) play such vital roles in development, that in the absence of hormone signals can still induce ductal and lobuloalveolar development.
EGFR is located on the surface of cells throughout the body. When activated by different cytokines, receptors dimerize and initiates downstream signaling via its intracellular tyrosine kinase domains.
Dimerization stimulates the intracellular tyrosine kinase domains. This begins a process where several tyrosine residues are autophosphorylated. (Y992, Y1068, Y1148, Y1173 ). Downstream signaling following this includes MAPK, Akt, and HNK pathways. These lead to both DNA synthesis and cellular proliferation. If this process becomes uncontrolled, an unfortunate disease state develops.
Inactive EGFR 3D Animation
Tyrosine Kinases exist in two distinct states, inactive and active. Inactive states are marked by their contracted a-loop with a closed N-lobe. When closed, the ATP binding pocket of the tyrosine kinase is blocked. and tyrosine residues are protected from phosphorylation. In the active state, the a-loop is extended with an open N-lobe revealing the ATP-binding pocket of the kinase.
Role in Health and Disease
Mutations in EGFR lead to overexpression of proteins and different types of cancers as cells continually and proliferate. Advancements in drug design allow for the continued binding of small molecules despite mutations. These compounds prevent kinase phosphorylation and down-regulate EGFR signals.
Mutant Active EGFR 3D Animation
Cancer isn't the only issue. Psoriasis, eczema, and atherosclerosis are all implicated in over-expression of EGFR. This is not well understood yet, but likely due to over-expression of inflammatory cytokines that initiate EGFR phosphorylation.
A common strategy of small molecule inhibitors is to identify receptors and examine their intra-cellular kinase domains. In many cases, this prevents aberrant behaviors in the receptor and mitigate the develop of disease. An easy target for this inhibition process is the kinase domain's ATP binding pocket. It has a high affinity for its ligand and phosphorylation of its tyrosine residue a requirement for signal propagation.
3D Print EGFR Tyrosine Kinase
3D printed protein models available in multiple sizes and materials. Contact us if you'd like to request a customization: CONTACT
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