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Nucleosome 3C1B

Nucleosome, Biologic Models, 3C1B

A Nucleosome is the basic structural unit of DNA that assemble into a chromosome. Each nucleosome consists of a segment of DNA wound in sequence around eight histone protein cores. This structure is often compared to thread wrapped around a spool.  Use this 3D printed model of DNA wrapped around a histone core to explain how DNA is…

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RSV Postfusion Glycoprotein

RSV, Fusion, Glycoprotein, Prefusion, 3rrr

Deadly to newborn babies, the Human Respiratory Syncytial Virus (HSV) is a major cause of lower respiratory tract infection. Dynamic structural changes in the Fusion F Glycoprotein reveal and hide binding sites, making targets of new therapies difficult to identify. Explore RSV Fusion F Glycoprotein-3RRR and learn more about its Postfusion 3D structure. (more…)

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Psilocybin bound to Serotonin Receptor

Psilocybin, 4ib4, Biologic Model, Molecular Model

Psilocybin bound to Serotonin Receptor Psilocybin, the active ingredient in psychoactive mushrooms, has provided the spiritual and cultural bedrock of many great civilisations. The Aztecs referred to teonanácatl, which translates as ‘divine mushroom’, and modern neuroscience has revealed how psilocybin interacts with serotonin receptors in the brain in order to produce a range of consciousness-altering effects.…

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Argonaute Protein

Argonaute Protein Small RNA sequences guide Argonaute Protein (Apo) to its specific DNA targets, which then leads to mRNA cleavage or translation inhibition. Inside the gut, bacteria express control over their host organism by secreting Nitric Oxide which modulates Apo function. Explore the 3D structure of Argonaute Protein. (more…)

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Human Cytomegalovirus

3D Print HCMV

The Human Cytomegalovirus (HCMV) is the leading cause of viral birth defects. HCMV Pentamer Complex is considered a key target candidate for vaccine therapies. How HCMV avoids humoral immunity is not clear. New research into the elusive virus reveals the surprising role of the host cell’s endoplasmic reticulum to aid viral infection. (more…)

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TDP-43 Wild Type and Mutant in Complex with DNA

TDP-43, ALS, Biologic Models

TDP-43 Wild Type and Mutant in Complex with DNA ALS is a fatal motor neuron disorder characterized pathologically by TAR DNA binding protein ( TDP-43 ). The function of TDP-43 is uncertain, and role in ALS remains speculative. Genome scanning reveals mutations associated to neural apoptosis. (more…)

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EGFR Mutant Tyrosine Kinase

EGFR, Mutant, Biologic Models

EGFR Mutant Tyrosine Kinase Mutations in EGFR lead to over-expression of proteins and different types of cancers as cells continually and proliferate. This 3D print of EGFR Tyrosine Kinase visualizes the mutations of key residues that lock the protein’s A-loop (orange) in its active conformation resulting in continued cellular proliferation. (more…)

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Monoclonal IgG4 Antibody bound to PD1

Pembrolizumab, ( KEYTRUDA ), PD1, Keytruda, Biologic Models

Monoclonal IgG4 Antibody bound to PD1 Humanized antibody are used in cancer immunotherapy to target the programmed cell death receptor (PD-1). Without the PD-1 protective mechanism, the antibody allows the immune system to destroy cancer cells. Explore the 3D structure with our interactive 3D models. (more…)

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Oxygenated Hemoglobin Hb

Oxygenated Hemoglobin Hb Hemoglobin, the protein from inside red blood cells, transports oxygen molecules throughout the body. Its macro-molecular symmetrical structure just the first interesting characteristic of this fascinating molecule. Explore its 3D structure with our 3D printed protein models of Oxygenated Hemoglobin Hb. (more…)

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Muscarinic Acetylcholine Receptor

Muscarinic Acetylcholine Receptor, 3UON

Muscarinic Acetylcholine Receptor 3UON Muscarinic acetylcholine receptors are G protein-coupled receptor complexes in the cell membranes of certain neurons and cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibers in the parasympathetic nervous system. This 3D printed protein model of muscarinic acetylcholine receptor is visualized by its ribbon structure highlighting the protein’s transmembrane active sites. (more…)

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RSV Prefusion Glycoprotein

RSV, Fusion, Glycoprotein, Prefusion, 5TDL

This is a 3D print of the RSV Fusion Glycoprotein in its prefusion state. The 3D printed protein models of RSV Fusion F Glycoprotein visualize the conformational changes of this viral protein during membrane fusion. Two chains are colored shades of magenta, with the third chain colored blue to red from N to C-Terminal. (more…)

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