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TDP-43 Wild Type and Mutant in Complex with DNA

TDP-43, ALS, Biologic Models

TDP-43 Wild Type and Mutant in Complex with DNA ALS is a fatal motor neuron disorder characterized pathologically by TAR DNA binding protein ( TDP-43 ). The function of TDP-43 is uncertain, and role in ALS remains speculative. Genome scanning reveals mutations associated to neural apoptosis. (more…)

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EGFR Mutant Tyrosine Kinase

EGFR, Mutant, Biologic Models

EGFR Mutant Tyrosine Kinase Mutations in EGFR lead to over-expression of proteins and different types of cancers as cells continually and proliferate. This 3D print of EGFR Tyrosine Kinase visualizes the mutations of key residues that lock the protein’s A-loop (orange) in its active conformation resulting in continued cellular proliferation. (more…)

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Monoclonal IgG4 Antibody bound to PD1

Pembrolizumab, ( KEYTRUDA ), PD1, Keytruda, Biologic Models

Monoclonal IgG4 Antibody bound to PD1 Humanized antibody are used in cancer immunotherapy to target the programmed cell death receptor (PD-1). Without the PD-1 protective mechanism, the antibody allows the immune system to destroy cancer cells. Explore the 3D structure with our interactive 3D models. (more…)

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Oxygenated Hemoglobin Hb

Oxygenated Hemoglobin Hb Hemoglobin, the protein from inside red blood cells, transports oxygen molecules throughout the body. Its macro-molecular symmetrical structure just the first interesting characteristic of this fascinating molecule. Explore its 3D structure with our 3D printed protein models of Oxygenated Hemoglobin Hb. (more…)

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RSV Prefusion Glycoprotein

RSV, Fusion, Glycoprotein, Prefusion, 5TDL

This is a 3D print of the RSV Fusion Glycoprotein in its prefusion state. The 3D printed protein models of RSV Fusion F Glycoprotein visualize the conformational changes of this viral protein during membrane fusion. Two chains are colored shades of magenta, with the third chain colored blue to red from N to C-Terminal. (more…)

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Oligosaccharyltransferase Complex

Oligosaccharyltransferase Complex, OST, ETH Zurich, Biologic Models

Oligosaccharyltransferase Complex This is a 3D print of oligosaccharyltransferase (OST) complex. It is colored blue according to the protein’s electrostatic property. Colored green are various monosaccharides attached to OST as sugar trees. Isolated and colored by atom type are the binding residues that attach shuttling proteins. Colored white are individual phospholipids from a plasma membrane.…

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