Category: ALS

Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease (MND) or Lou Gehrig’s disease, is a disease that causes the death of neurons controlling voluntary muscles.

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TDP-43 Wild Type and Mutant in Complex with DNA

TDP-43, ALS, Biologic Models

TDP-43 Wild Type and Mutant in Complex with DNA ALS is a fatal motor neuron disorder characterized pathologically by TAR DNA binding protein ( TDP-43 ). The function of TDP-43 is uncertain, and role in ALS remains speculative. Genome scanning reveals mutations associated to neural apoptosis. (more…)

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