Project
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Mechanism of Insulin Action
Insulin is a small 51 residue hormone synthesized and secreted by ß cells in the pancreas. Insulin is central to lowering blood glucose and maintaining metabolic function. Diabetes Educators and healthcare providers use this set of 3D printed models to explain how insulin binds the insulin receptor, calls up Glucose Transporters to the plasma membrane so that Glucose molecules can then flow through to the inside the cell.
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DXP Synthase 6OUV-6OUW
3D Print of DXP Synthase in both its "Open" and "Closed" states. Protein dataset color-coded to denote active loops and binding motifs while highlighting three active site Histidine residues by their heteroatom color. The base for 3D prints includes a QR Code link to a 3D animated molecular visualization of DXP Synthase changing conformation from its 'Open' to 'Closed' states.
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SARS-CoV-2 Structural Proteins
The outbreak of a novel coronavirus (SARS-CoV-2) represents a pandemic threat that has been declared a public health emergency of international concern. The structural proteins of the SARS-CoV-2 Virion are key targets for vaccines, therapeutic antibodies, and diagnostics. Biologic Model designed the 3D printed SARS-CoV-2 Virion Model to help scientists better visualize the structural assembly of viral proteins. This scientific model is being used to help facilitate the rapid development and evaluation of medical countermeasures to address the ongoing public health crisis.
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Oligosaccharyltransferase Complex
ETH Zurich makes major breakthrough in diabetes research after crystallizing Oligosaccharyltransferase (OST) Complex, the sugar attaching protein.
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Antibody Drug Conjugate
Antibody Drug Conjugate (ADCs) are monoclonal antibodies attached to biologically active drugs by chemical linkers. These cytotoxic killers are a new frontier in immunotherapy offering tissue targeting capabilities for superior immunological response. Explore the 3D structure of an Antibody Drug Conjugate to learn more about how it combats cancer.
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Nucleosome
A nucleosome is a basic unit of DNA, consisting of a segment of DNA wound in sequence around eight histone protein cores. This structure is often compared to thread wrapped around a spool. Explore the 3D structure of Nucleosome 3C1B to learn more about DNA coiling.
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CRISPR-Cas9 Bound to Guide RNA and Target DNA
This is a 3D print of CRISPR Ca9 is created in full-color sandstone. The model depicts CRISPR (purple) bound to its guide RNA (red) while editing its Target DNA (yellow and green). The subtle color variations in the CRISPR are associated with its bFactor, or atomic temperature. The darker the color, the less the protein moves with a cooler atomic temperature.
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Psilocybin bound to Serotonin Receptor
Modern neuroscience reveals how psilocybin interacts with serotonin receptors in the brain in order to produce a range of consciousness-altering effects.
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Glycated Hemoglobin HbA1c
Learn more about the dangers of high blood sugar and the HbA1c blood test by exploring this 3D Printed Protein Model of Glycated Hemoglobin (HbA1c).
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CRISPR-Cas13a Bound to Guide RNA and Target RNA
CRISPR-Cas13a is a newly discovered member of the Genome editing system making waves in the biotech community. Explore this 3D printed protein model of CRISPR-Cas13a to examine how it uses RNA to target and edit DNA. Protein model created from PDB ID: 5XWP
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GLP-1 Comparative Analysis
Use these 3D prints of GLP-1 to explain the incretin effect and compare GLP-1 to its analogs. The set includes the natural GLP-1 hormone, an natural animal analog, and synthetic drug.
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Oxygenated Hemoglobin Hb
Hemoglobin, the protein from inside red blood cells, transports oxygen molecules throughout the body. Explore its 3D structure with a 3D printed biologic model of Oxygenated Hemoglobin Hb.
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Ebola Virus Ectodomain
In this 3D exploration of the Ebola Virus Glycoprotein, we will investigate different surface properties and binding sites through 3D printed models and animation.
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Insulin Receptor Complex
Insulin is a chemical messenger produced by the pancreas in response to food. Use this 3D printed Biologic Model of the Insulin Receptor Complex as a desktop reminder to take your medication before each meal.
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EGFR Tyrosine Kinase
An investigation of the structural differences between wild type and mutant EGFR Tyrosine Kinase in order to understand oncogenic cellular proliferation.
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RSV Fusion F Glycoprotein
Deadly to newborn babies, the Human Respiratory Syncytial Virus (HSV) is a major cause of lower respiratory tract infection. Dynamic structural changes in the Fusion F Glycoprotein reveal and hide binding sites, making targets of new therapies difficult to identify. Explore RSV Fusion F Glycoprotein-3RRR and learn more about its Postfusion 3D structure.
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CRISPR-Cpf1 Bound to Guide RNA and Target DNA
Explore the internal secondary structures of CRISPR-Cpf1 with this 3D Printed Protein Model and free Augemented Reality App.
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Protected: Human Cytomegalovirus HCMV
The Human Cytomegalovirus (HCMV) is the leading cause of viral birth defects. HCMV Pentamer Complex is the main target of a viral immune response, and considered a key target candidate for vaccine therapies.
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M Tuberculosis Toxin-antitoxin Complex
Tuberculosis is one of the top 10 causes of death worldwide, killing 10 million people around the world in 2017. Researchers at EMBL in Hamburg recently discovered that the Tuberculosis bacteria has a special toxin system with a surprising function. Once the system activated, all bacterial cells die and stop the disease.
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Monoclonal IgG4 Antibody bound to PD1
This is a 3D print of a humanized monoclonal IgG4 antibody used in multiple types of cancer treatments. Models available in multiple materials and sizes.