The SARS-CoV1 Spike Glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. Biologic Models designed this 3D printed protein model of the SARS-CoV1 Receptor Binding Domain 5X58 to help research scientists and the general public better understand the binding properties of the Spike Glycoprotein and how it compares to other Coronavirus Spike Glycoproteins.…
Category: Pathophysiology
Pathophysiology – a convergence of pathology with physiology – is the study of the disordered physiological processes that cause, result from, or are otherwise associated with a disease or injury.
SARS-CoV-2 RNA Polymerase inhibited by Remdesivir
The outbreak of a novel coronavirus (SARS-CoV-2) represents a pandemic threat that has been declared a public health emergency of international concern. The SARS-CoV-2 RNA Polymerase is a key target for antiviral therapy. The 3D printed structure of SARS-CoV-2 RNA Polymerase inhibited by Remdesivir should enable the rapid development and evaluation of medical countermeasures to address…
M Tuberculosis Toxin-antitoxin Complex
Cannabinoid Receptor CB1 5TGZ
Cannabinoid receptors are part of the endocannabinoid system, which is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory. This 3D print of THC Cannabinoid Receptor Complex 5TGZ is designed to visualize THC bound inside the receptor-binding pocket. (more…)
Nucleosome 3C1B
A Nucleosome is the basic structural unit of DNA that assembles into a chromosome. Each nucleosome consists of a segment of DNA wound in sequence around eight histone protein cores. This structure is often compared to thread wrapped around a spool. Use this 3D printed model Nucleosome 3C1B showing how DNA wraps around a histone core to explain…
RSV Postfusion Glycoprotein
Deadly to newborn babies, the Human Respiratory Syncytial Virus (HSV) is a major cause of lower respiratory tract infection. Dynamic structural changes in the Fusion F Glycoprotein reveal and hide binding sites, making targets of new therapies difficult to identify. Explore RSV Fusion F Glycoprotein-3RRR and learn more about its Postfusion 3D structure. (more…)
Glycated Hemoglobin HbA1c
Human Insulin Hexamer
Psilocybin bound to Serotonin Receptor
Psilocybin bound to Serotonin Receptor Psilocybin, the active ingredient in psychoactive mushrooms, has provided the spiritual and cultural bedrock of many great civilizations. The Aztecs referred to teonanácatl, which translates as ‘divine mushroom’, and modern neuroscience has revealed how psilocybin interacts with serotonin receptors in the brain in order to produce a range of consciousness-altering…
Argonaute Protein
Argonaute Protein Small RNA sequences guide Argonaute Protein (Apo) to its specific DNA targets, which then leads to mRNA cleavage or translation inhibition. Inside the gut, bacteria express control over their host organism by secreting Nitric Oxide which modulates Apo function. Explore the 3D structure of Argonaute Protein. (more…)
Human Cytomegalovirus
The Human Cytomegalovirus (HCMV) is the leading cause of viral birth defects. HCMV Pentamer Complex is considered a key target candidate for vaccine therapies. How HCMV avoids humoral immunity is not clear. New research into the elusive virus reveals the surprising role of the host cell’s endoplasmic reticulum to aid viral infection. (more…)
Nucleosome 1KX5
TDP-43 Wild Type and Mutant in Complex with DNA
TDP-43 Wild Type and Mutant in Complex with DNA ALS is a fatal motor neuron disorder characterized pathologically by TAR DNA binding protein ( TDP-43 ). The function of TDP-43 is uncertain, and role in ALS remains speculative. Genome scanning reveals mutations associated to neural apoptosis. (more…)
Zika Virus Shell
EGFR Mutant Tyrosine Kinase
EGFR Mutant Tyrosine Kinase Mutations in EGFR lead to over-expression of proteins and different types of cancers as cells continually and proliferate. This 3D print of EGFR Tyrosine Kinase visualizes the mutations of key residues that lock the protein’s A-loop (orange) in its active conformation resulting in continued cellular proliferation. (more…)
EGFR Wild Type Tyrosine Kinase
Humalog Insulin Hexamer
CRISPR-Cas13a
Cytochrome MtrC
Monoclonal IgG4 Antibody bound to PD1
Monoclonal IgG4 Antibody bound to PD1 Humanized antibody are used in cancer immunotherapy to target the programmed cell death receptor (PD-1). Without the PD-1 protective mechanism, the antibody allows the immune system to destroy cancer cells. Explore the 3D structure with our interactive 3D models. (more…)