Pathophysiology – a convergence of pathology with physiology – is the study of the disordered physiological processes that cause, result from, or are otherwise associated with a disease or injury.
Poliovirus Type 2 This is 3D protein model of the Poliovirus Type 2 3D printed in full-color sandstone or plastic and colored to denote the locations of active residues targeted by antibodies. Despite the Type 2 wild poliovirus being declared eradicated in September 2015, a vaccine-derived mutated version of the vaccine-virus has reemerged in…
Serotonin receptors are activated by the neurotransmitter like serotonin, which acts as their natural ligand. Other endogenous small molecules, like N-dimethyltryptamine (DMT) and Lysergic acid diethylamide (LSD), competitively bind Serotonin Receptors producing transcendental psychedelic effects. (more…)
Enjoy you morning cup of #Coffee along side this #3DPrint of the Adenosine Receptor in Complex with Caffeine 5MZP . The Adenosine Receptor is tinted shades of brown and the #Caffeine small molecule colored by atom type. (more…)
Cannabinoid receptors are part of the endocannabinoid system, which is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory. This 3D print of THC Cannabinoid Receptor Complex 5TGZ is designed to visualize THC (color by atom type) bound inside the receptor-binding pocket. (more…)
The severe acute respiratory syndrome (SARS) coronavirus 2 (CoV-2) variant Omicron spread more rapid than the other variants of SARS-CoV-2 virus. Simulation results show that the Omicron Variant have stronger binding to ACE2 than other variants. Biologic Models designed this 3D printed protein model of the SARS-CoV-2 Receptor Binding Domain Omicron Mutant 6VXX helps research…
The SARS-CoV2 Delta Plus variant was first reported in India. This new variant, was shown to carry mutation K417N on its receptor-binding domain (RBD), a mutation previously reported in the Beta variant. Experts believe it contributes to immune evasion in SARS-CoV-2 and synergistic with mutation L452R, another mutation known to also contribute to immune evasion.…
The SARS-CoV-2 Spike Glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. Biologic Models designed this 3D printed protein model of the SARS-CoV-2 Receptor Binding Domain (RBD) ACE2 Receptor Complex 6M17 to help research scientists and the general public better understand how SARS-CoV-2 binds ACE2 Receptors. (more…)
The SARS-CoV-2 Spike Glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. Biologic Models designed this 3D printed protein model of the SARS-CoV-2 Receptor Binding Domain Neutralizing Antibody Complex 7KS9 to help research scientists and the general public better understand how to neutralize Spike Glycoprotein. (more…)
The SARS-CoV-2 Spike Glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. Biologic Models designed this 3D printed protein model of the SARS-CoV-2 Receptor Binding Domain 6VXX to help research scientists and the general public better understand the binding properties of the Spike Glycoprotein and how it compares to other Coronavirus Spike Glycoproteins.…
The outbreak of a novel coronavirus (SARS-CoV-2) represents a pandemic threat that has been declared a public health emergency of international concern. The SARS-CoV-2 Spike Glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. Biologic Models designed this 3D printed protein model of the SARS-CoV-2 Spike Glycoprotein 7KS9 to help scientists better visualize…
The outbreak of a novel coronavirus (SARS-CoV-2) represents a pandemic threat that has been declared a public health emergency of international concern. The SARS-CoV-2 Spike Glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. Biologic Models designed this 3D printed protein model of the SARS-CoV-2 Spike Glycoprotein Postfusion 6XRA to help scientists better…
A nucleosome is a structural unit of a eukaryotic chromosome, consisting of a length of DNA coiled around a core of histones. (more…)
The outbreak of a novel coronavirus (SARS-CoV-2) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV Spike Glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. The 3D printed structure of SARS-CoV-2 Spike Glycoprotein ACE2 Complex 6VXX-6M17 is designed to enable the rapid development and…
This 3D printed protein model of SARS-CoV-2 Spike Glycoprotein 3D printed and colored-coded to denote functional domains (NTD blue, RBD green, SD1, light tan, SD2 red-orange-yellow, FP cyan, RRAR brown). (more…)
Negative-strand (NS) RNA viruses initiate infection with a unique polymerase complex. This protein complex mediates both mRNA transcription and subsequent genomic RNA replication. Domains for both functional interactions are contained within a single Large polymerase protein (L-protein). (more…)
High-density lipoprotein (HDL), the carrier of so-called “good” cholesterol, serves as the major athero-protective lipoprotein and has emerged as a key therapeutic target for cardiovascular disease. (more…)
Human cytomegalovirus (HCMV) poses a significant threat to immunocompromised individuals and neonates infected in utero. Glycoprotein B (gB), the herpesvirus fusion protein, is a target for neutralizing antibodies and a vaccine candidate due to its indispensable role in infection. HCMV is the leading infectious cause of congenital abnormalities in the Western world including hearing loss.…
Penicillin acylases (PA) participates in penicillin and cephalosporin biosynthesis. Penicillin acylases (PA) are widely used for the production of semi-synthetic β-lactam antibiotics and chiral compounds. (more…)
CRISPR-Cas13d CRISPR Cas13a is a newly discovered member of the Genome editing system making waves in the biotech community. Explore this 3D printed protein model of CRISPR Cas13a to examine how it uses RNA to target and edit viral RNA. Protein model created from PDB ID: 6IV9 (more…)
CRISPR Cas13d in Complex with crRNA CRISPR Cas13a is a newly discovered member of the Genome editing system making waves in the biotech community. Explore this 3D printed protein model of CRISPR Cas13d (tinted green) to examine how it uses RNA (red) to target and edit viral RNA (purple). Protein model created from PDB ID:…
