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Human Cytomegalovirus HCMV Glycoprotein B

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Human cytomegalovirus (HCMV) poses a significant threat to immunocompromised individuals and neonates infected in utero. Glycoprotein B (gB), the herpesvirus fusion protein, is a target for neutralizing antibodies and a vaccine candidate due to its indispensable role in infection. HCMV is the leading infectious cause of congenital abnormalities in the Wwestern world

Protein Description 5C6T

HCMV Glycoprotein B (gB), the herpesvirus fusion protein, is a key target for neutralizing antibodies and a vaccine candidate due to its indispensable role in infection. Here we show the crystal structure of the HCMV gB ectodomain bound to the Fab fragment of 1G2, a neutralizing human monoclonal antibody.

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The gB/1G2 interaction is dominated by aromatic residues in the 1G2 heavy chain CDR3 protruding into a hydrophobic cleft in the gB antigenic domain 5 (AD-5).

Model Description

Biologic Model of Human Cytomegalovirus HCMV Glycoprotein B 5C6T 3D printed in full-color sandstone.