Penicillin acylases (PA) participates in penicillin and cephalosporin biosynthesis. Penicillin acylases (PA) are widely used for the production of semi-synthetic β-lactam antibiotics and chiral compounds.
Protein Description 1FXV
Penicillin acylases (PA) are widely used for the production of semi-synthetic β-lactam antibiotics and chiral compounds. The binding of penicillin to penicillin acylase was studied by X-ray crystallography. Binding of the substrate induces a conformational change, in which the side chains of alphaF146 and alphaR145 move away from the active site, which allows the enzyme to accommodate penicillin G.
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PA contains 2 non-identical subunits. The larger β subunit contains a phenylmethylsulfonyl residue which is required for enzymatic activity.
Model Description
Biologic Model of Penicillin Acylase Complex created from PDB ID: 1FXV and 3D printed in full-color sandstone.