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Superhelix Model of High-Density Lipoprotein HDL

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High-density lipoprotein (HDL), the carrier of so-called “good” cholesterol, serves as the major athero-protective lipoprotein and has emerged as a key therapeutic target for cardiovascular disease.

Protein Description 3K2S

HDL is observed to possess an open helical shape that wraps around a central ellipsoidal lipid phase. The double superhelix model, suggest an unexpected structural arrangement of protein and lipids of nascent HDL, an anti-parallel double superhelix wrapped around an ellipsoidal lipid phase.

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The protein and lipid organization in nascent HDL envisages a potential generalized mechanism for lipoprotein biogenesis and remodeling, biological processes critical to sterol and lipid transport, organismal energy metabolism, and innate immunity.

Model Description

Biologic Model of Superhelix Model of High-Density Lipoprotein HDL created from PDB ID: 3K2S 3D printed in full-color sandstone.