High-density lipoprotein (HDL), the carrier of so-called “good” cholesterol, serves as the major athero-protective lipoprotein and has emerged as a key therapeutic target for cardiovascular disease.
Protein Description 3K2S
HDL is observed to possess an open helical shape that wraps around a central ellipsoidal lipid phase. The double superhelix model, suggest an unexpected structural arrangement of protein and lipids of nascent HDL, an anti-parallel double superhelix wrapped around an ellipsoidal lipid phase.
The protein and lipid organization in nascent HDL envisages a potential generalized mechanism for lipoprotein biogenesis and remodeling, biological processes critical to sterol and lipid transport, organismal energy metabolism, and innate immunity.
Biologic Model of Superhelix Model of High-Density Lipoprotein HDL created from PDB ID: 3K2S 3D printed in full-color sandstone.