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T Cell Receptor CD3 Hexamer Complex

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T-cell receptors (TCR) are a protein complex found on the surface of T cells that are responsible for identifying fragments of antigen bound to major histocompatibility complex (MHC) molecules.

Protein Description 6JXR

The αβ T cell receptor (TCR), in association with the CD3γε-CD3δε-CD3ζζ signalling hexamer, is the primary determinant of T cell development and activation, and of immune responses to foreign antigens. The mechanism of assembly of the TCR-CD3 complex remains unknown. Here we report a cryo-electron microscopy structure of human TCRαβ in complex with the CD3 hexamer at 3.7 Å resolution. 

Biologic Explorer 6JXR

Model Description

Biologic Model of T Cell Receptor CD3 Hexamer Complex created from PDB ID: 6JXR 3D printed in full-color sandstone.