The crystal structure of an HJURP-CENP-A-histone H4 complex shows that HJURP binds a CENP-A-H4 heterodimer. The C-terminal ?-sheet domain of Holiday Junction caps the DNA-binding region of the histone heterodimer, preventing it from spontaneous association with DNA
Biologic Explorer: 3R45
Protein visualized by ribbon backbone with the Holiday Junction helices colored red and beta sheets colored cyan, active sites that bind DNA colored by atom type.
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