Nuclear Pore Complex
Nuclear pore complexes (NPCs) mediate the transport of proteins and molecules into the nucleus of cells. Dynamic structural changes enable this movement. This 3D printed molecular model of NPC 7R5K captures the pore in its constricted state.
Biologic Explorer: Nuclear Pore Complex 7R5K
Protein Description
The eukaryotic nucleus protects the genome and is enclosed by the two membranes of the nuclear envelope. Nuclear pore complexes (NPCs) perforate the nuclear envelope to facilitate nucleocytoplasmic transport. With a molecular weight of ∼120 MDa, the human NPC is one of the largest protein complexes. The architecture of a Nuclear Pore Complex is dynamic. It responds to changes in nuclear envelope tension with conformational breathing that manifests in dilation and constriction movements.
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