This cytotoxic drug utilizes their innovative Engineered Toxic Bodies (ETBs) drug delivery platform to trigger cell death. MT-3724 is being developed for the treatment of non-Hodgkin’s Lymphoma and harnesses the immunotherapy power of antibody receptor-specific targeting combined, a bacterial process for cell invasion that infects cancer cells with ribosomal inhibitors that strangle protein synthesis. MT-3724 demonstrates a unique mechanism of action, packing a cytotoxic 1-2-3 cancer killing punch.
MT-3724’s Mechanism of Action
While targeting CD20 antigens using anti-CD20 FAB fragments is nothing new for oncology treatments, Molecular Templates is using a completely new and revolutionary approach to initiate a cytotoxic immune response. The ETB platform is robust, combining multiple unique mechanisms into a single immunotoxin.
- It targets cancer cells using anti-CD FABs
- Tags cancer cells for an immune response using viral antigen
- Kill tumor cells by stopping ribosomal protein synthesis, effectively halting nuclear function.
Molecular Templates explains:
“Molecular Templates has developed an engineered toxin body (ETB) platform, a next-generation recombinant immunotoxin scaffold based on the Shiga-like toxin A subunit (SLT-1A) specifically directed to cancer cells via antibody fragment binding domains. The ETB scaffold is engineered to force the internalization of receptors that typically do not internalize or internalize poorly. Molecular Templates’ lead compound, MT-3724, is the first immunotoxin targeting CD20 to enter the clinic and is currently in a phase I study for refractory non-Hodgkin’s Lymphoma.
“Additionally, we have taken advantage of the immunotoxin’s localization to the cytosol to engineer in a novel immuno-oncology mechanism of action. Molecular Templates’ Antigen Seeding Technology involves genetically fusing MHC class I antigens derived from human cytomegalovirus (HCMV) to the immunotoxin scaffold in order to mark these cells as targets for cytotoxic T lymphocyte (CTL) mediated cell lysis. Because antigen presentation does not require de novo protein synthesis, this mechanism of action is complementary to the inactivation of ribosomal function by the SLT-1 A domain of the ETBs. Since a large portion of the populace has a robust population of high-affinity effector T-cells targeting HCMV, the presentation of these antigens on ETB-intoxicated cancer cells may recruit a pre-existing CTL response to tumor cells. The recruitment of a CTL response has the potential to act additively or synergistically to the direct cell kill activity of the ETB and may expand the efficacy of these immunotoxins.”
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MT-3724 bound to CD20
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