Shiga Toxin


This is a 3D print of Shiga Toxin (Stk1) created from protein dataset 1DM0  This model is colored by protein chain. The 5 blue chains are the membrane binding domains and the red the cytotoxic compounds.


Protein Description

Shigella dysenteriae is the pathogen responsible for the severe form of dysentery in humans. It produces Shiga toxin, the prototype of a family of closely related bacterial protein toxins. We have determined the structure of the holotoxin, an AB5 hexamer, by X-ray crystallography. The five B subunits form a pentameric ring, encircling a helix at the carboxy terminus of the A subunit. The A subunit interacts with the B pentamer via this C-terminal helix and a four-stranded mixed beta-sheet. The fold of the rest of the A subunit is similar to that of the A chain of the plant toxin ricin; both are N-glycosidases. However, the active site in the bacterial holotoxin is blocked by a segment of polypeptide chain. These residues of the A subunit would be released as part of the activation mechanism of the toxin.

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Learn more about Shiga Toxin.




Additional information

Weight 1 lbs
Dimensions 8 x 8 x 4 cm

Small, Medium, Large

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