Angiopoietin-2/Tie2 Complex 2gy7

This is a biologic model of Angiopoietin-2/Tie2 Complex 2gy7 3D printed in full-color sandstone.

SKU: 1373766582374-angiopoietin-2-tie2-complex Category: Tags: , ,


This is a biologic model of Angiopoietin-2/Tie2 3D printed in full-color sandstone.

Protein Description
The Tie receptor tyrosine kinases and their angiopoietin (Ang) ligands play central roles in developmental and tumor-induced angiogenesis. In contrast to prediction, Tie2 contains not two but three immunoglobulin (Ig) domains, which fold together with the three epidermal growth factor domains into a compact, arrowhead-shaped structure. Ang2 binds at the tip of the arrowhead utilizing a lock-and-key mode of ligand recognition-unique for a receptor kinase-where two complementary surfaces interact with each other with no domain rearrangements and little conformational change in either molecule. 

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Complex created from PDB ID: 2gy7