Zejula is a selective inhibitor of PARP1 and PARP2. The mechanisms by which Zejula inhibits polyADP-ribose (PARP) is revealed to insert a flexible moiety into the phophobic subpocket of PARP1.
Biologic Model of PARP1 (cyan) bound by Zejula (red) and 3D printed in full color sandstone.
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Created from PDB ID: 4r6e