A nucleosome is a structural unit of a eukaryotic chromosome, consisting of a length of DNA coiled around a core of histones.
The effect of H3 K79 dimethylation and H4 K20 trimethylation on nucleosome and chromatin structure
Histone methylation regulates chromatin function dependent on the site and degree of the modification. In addition to creating binding sites for proteins, methylated lysine residues are likely to influence chromatin structure directly. Here we present crystal structures of nucleosomes reconstituted with methylated histones and investigate the folding behavior of resulting arrays. We demonstrate that dimethylation of histone H3 at lysine residue 79 locally alters the nucleosomal surface, whereas trimethylation of H4 at lysine residue 20 affects higher-order structure.
Created from PDB ID: 3C1B