Biologic model of the Human Cytomegalovirus (HCMV) Pentamer Complex 3D printed in full-color sandstone. Model is colored by protein chain. (Chain A gH: Grey, Chain B gL: Green, Chain C UL128: Pink, Chain D UL130: Yellow, Chain E UL131: Blue)
Human cytomegalovirus (HCMV) is the leading viral cause of birth defects and organ transplant rejection. The HCMV gH/gL/UL128/UL130/UL131A complex (Pentamer) is the main target of humoral responses and thus a key vaccine candidate. The extension of gL forms a subdomain composed of a three-helix bundle and a β hairpin that acts as a docking site for UL128/UL130/UL131A. Structural analysis reveals that Pentamer is a flexible molecule, and suggests sites for engineering stabilizing mutations.
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Created from PDB ID: 5VOB