This is an atomic model of Amylin showcasing the CPK visualizing style. Each sphere is sized according to the atom’s atomic weight.
Human islet amyloid polypeptide is a hormone coexpressed with insulin by pancreatic beta-cells. For reasons not clearly understood, hIAPP aggregates in type II diabetics to form oligomers that interfere with beta-cell function, eventually leading to the loss of insulin production. The cellular membrane catalyzes the formation of amyloid deposits and is a target of amyloid toxicity through the disruption of the membrane’s structural integrity.
Created from PDB ID:2l86