Sale!
fullColor_Sandstone_50%

Insulin Receptor bound by Insulin

$85.02$1,681.78 $85.02$1,519.99

This is a 3D print of the Insulin Receptor in complex with Insulin. This model is generated from PDB IDs:  3Wi4 and 2MFR. It is color coded to denote the dimer configuration on the plasma membrane.

Clear

Product Description

Model Description

Insulin Receptor printed in full-color sandstone. Receptor dimer chains colored blue and green. Insulin chains A and B colored Orange and Yellow)

3D Molecular Visualization

 

Insulin Receptor bound by Insulin Protein Description

The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of tyrosine kinase receptors.[5] Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis, a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer.[6][7] Biochemically, the insulin receptor is encoded by a single gene INSR, from which alternate splicing during transcription results in either IR-A or IR-B isoforms.[8] Downstream post-translational events of either isoform result in the formation of a proteolytically cleaved α and β subunit, which upon combination are ultimately capable of homo or hetero-dimerisation to produce the ≈320 kDa disulfide-linked transmembrane insulin receptor.[8]

Model Gallery

Multiple sizes available, please visit our shapeways.com store for more options

Additional Information

Size

Small, Medium, Large

Reviews

There are no reviews yet.

Be the first to review “Insulin Receptor bound by Insulin”