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CRISPR Cpf1, Biologic Models,
3d Prints of CRISPR Cas9 and Cpf1

CRISPR Cpf1 Bound to Guide RNA and Target DNA

$25.39$696.71 $25.39$636.99

3D printed model of CRISPR Cpf1 in Coated Full Color Sandstone with a glossy and smooth finish. Made to order, printed and shipped directly to you. ~2 weeks plus shipping.

For customers outside of the US, please visit our shapeways.com store to purchase and ship the same models directly to you

https://www.shapeways.com/shops/biologicmodels

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Product Description

Model Description

This is a 3D print of CRISPR Cpf1. The model depicts CRISPR (blue) bound to its guide RNA (red) while editing its Target DNA (yellow and green). The subtle color variations in the CRISPR are associated with its bFactor, or atomic temperature. The darker the color, the less the protein moves with a cooler atomic temperature. Multiple sizes available, contact us for requests.

 Consider purchasing an Augmented Reality base for CRISPR Cpf1.

Protein Description

“Cpf1 is an RNA-guided endonuclease of a type V CRISPR-Cas system that has been recently harnessed for genome editing. Here, we report the crystal structure of Acidaminococcus sp. Cpf1 (AsCpf1) in complex with the guide RNA and its target DNA at 2.8 Å resolution. AsCpf1 adopts a bilobed architecture, with the RNA-DNA heteroduplex bound inside the central channel. The structural comparison of AsCpf1 with Cas9, a type II CRISPR-Cas nuclease, reveals both striking similarity and major differences, thereby explaining their distinct functionalities. AsCpf1 contains the RuvC domain and a putative novel nuclease domain, which are responsible for cleaving the non-target and target strands, respectively, and for jointly generating staggered DNA double-strand breaks. AsCpf1 recognizes the 5′-TTTN-3′ protospacer adjacent motif by base and shape readout mechanisms. Our findings provide mechanistic insights into RNA-guided DNA cleavage by Cpf1 and establish a framework for rational engineering of the CRISPR-Cpf1 toolbox.”

http://www.rcsb.org/pdb/explore/explore.do?structureId=5b43

CRISPR Cpf1 3D Molecular Animation

 

Additional Information

Size

Extra Small, Small, Medium, Large