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3D Print of CRISPR Cas9

CRISPR Cas9 Bound to Guide RNA and Target DNA

$27.68$783.59 $27.68$699.99

3D printed in Coated Full Color Sandstone with a glossy and smooth finish. Made to order, printed and shipped directly to you. ~2 weeks plus shipping.

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Product Description

Model Description

CRISPR Cas9 printed in full-color sandstone. RNA is colored red, DNA colored Yellow and Green. The subtle color variations in the CRISPR are associated with its bFactor, or atomic temperature. The darker the color, the less the protein moves with a cooler atomic temperature.

3D Molecular Visualization

CRISPR Cas9 Protein Description

“The RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA targets with a protospacer adjacent motif (PAM) and complementarity to the guide RNA. Recently, we harnessed Staphylococcus aureus Cas9 (SaCas9), which is significantly smaller than Streptococcus pyogenes Cas9 (SpCas9), to facilitate efficient in vivo genome editing. Here, we report the crystal structures of SaCas9 in complex with a single guide RNA (sgRNA) and its double-stranded DNA targets, containing the 5′-TTGAAT-3′ PAM and the 5′-TTGGGT-3′ PAM, at 2.6 and 2.7 Å resolutions, respectively. The structures revealed the mechanism of the relaxed recognition of the 5′-NNGRRT-3′ PAM by SaCas9. A structural comparison of SaCas9 with SpCas9 highlighted both structural conservation and divergence, explaining their distinct PAM specificities and orthologous sgRNA recognition. Finally, we applied the structural information about this minimal Cas9 to rationally design compact transcriptional activators and inducible nucleases, to further expand the CRISPR-Cas9 genome editing toolbox.”
https://www.ncbi.nlm.nih.gov/pubmed/26317473

Model Gallery

  • CRISPR Cas9

Multiple sizes available, contact us for requests.

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Medium, Small, Extra Small, Large