Hope on the Horizon is a 3D MOA medical animation depicting new theories about biochemical mechanism of disease and treatment of Alzheimer’s Disease.

Macro-molecular structures brought to life

This is an animation created for CogRx, a small biotech startup in Pittsburgh. This was an exciting project that brought to life the protein structures CogRx is currently investigating. For many structural biologists, the proteins they study are only glimpsed through test results, or piece-mail through visualization software. Our visualization scientists specialize at building complex macro-molecular structures. We work with structural biologists to then determine protein behaviors and interactions based on different surface properties, binding and active site locations.

 

Aligning Known Structures to Target Proteins

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Some proteins that we know interact have yet to be crystallized as bound structures. In order to better understand protein function and the cascade of events that result in cellular process, we work with structural biologists to theorize potential alignments and interactions.

Determining protein dynamics through data analysis

AB Oligomer Animation Test from Biologic Discovery on Vimeo.

Creating the 3D animation for the beta amyloid beta oligomer required significant research in order to determine viable conformation changes of individual monomers. Referencing Dr. Vijay Pande’s work at Stanford University to simulate AB oligomerization¬†http://www.ncbi.nlm.nih.gov/pubmed/19063575¬†, our medical animators developed this depiction of an AB oligomer movement.

Mechanism of Action 3D Animation

Hope on the Horizon from Biologic Discovery on Vimeo.

Often times, biotechs and startups need help explaining their insights to investors. This is a great example of how our work helped a bring in funding to conduct clinical trials. When presenting to investors, this 3D animation played behind presenters allowing lead scientists to narrate their product’s custom message.

Supplemental Promotional Material

To better help our clients secure further support for their research, we delivered a series of 3D illustrations like the one below depicting important ideas related to their products messaging.