fHbp, Fusion H-binding protein, Antibody, FAB, Biologic Models

3D Prints of FAB Antibody bound to Meningococcal fHbp

3D printed protein models of a FAB Antibody bound to Meningococcal fHbp. These models are designed to pair with the academic publication, Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp. (LINK )

(more…)

MT-3724, Biologic Models, Molecular Templates,

MT-3724 Realtime 3D Explorer

MT-3724 Protein Model

This is a theoretical model designed from the information contained in the publication listed below. MT-3724 is a unique immunotoxin assembled from a variety of other protein complexes. As an immunotoxin, MT-3724 packs a mean 1-2 punch, triggering apoptosis and an immune response by conjugating bacterial toxins onto an anti-CD20 FAB-fragment.  Learn more about this protein complex by exploring its 3D-structure.  (more…)

CRISPR Cpf1, Biologic Models,

3D Print CRISPR Cpf1

Configure and 3D Print in a variety of materials and sizes a hand-held model of CRISPR Cpf1. This model of Cpf1 can be 3D printed in a variety of materials and sizes. Seen here, Cpf1 is colored blue, DNA colors yellow and green, and guide RNA colored Red. Below is a photo of both our CRISPR Cpf1 and Cas9 models.

(more…)

Ebola, Virus, Biologic Models

3D Print Ebola Virus Ectodomain

Protein Description

“Ebolavirus (EBOV) is a highly virulent pathogen capable of causing a severe hemorrhagic fever with 50–90% lethality. The EBOV glycoprotein (GP) is the only virally expressed protein on the virion surface and is critical for attachment to host cells and catalysis of membrane fusion. Hence, the EBOV GP is a critical component of vaccines as well as a target of neutralizing antibodies and inhibitors of attachment and fusion. The crystal structure of the Zaire ebolavirus GP in its trimeric, prefusion conformation (3 GP1 plus 3 GP2) in complex with a neutralizing antibody fragment, derived from a human survivor of the 1995 Kikwit outbreak, was recently determined.

[caption id="attachment_4150" align="alignnone" width="1020"]Ebola Virus, Ectodomain, Biologic Models Ebola Virus Ectodomain Banner[/caption]

This is the first near-complete structure of any filovirus glycoprotein. The overall molecular architecture of the Zaire ebolavirus GP and its role in viral entry and membrane fusion are discussed in this article.”  — NCBI Citation

3D Animation

Ebola Virus Ectodomain in complex with Human Antibodies from Biologic Discovery on Vimeo.

The ebola virus has a natural enemy, the human immune system. Those lucky enough to survey this deadly virus produce an antibody which identifies the virus for destruction. The above animation shows these antibodies attached to the ectodomains of the virus.

Model Description

This is a 3D print of x-ray crystallography datasets PDB IDs: 3CSY, 2EBO  The protein surface color coding is defined by the glycoprotein’s Hydrophobicity. To delineate the different chains, we have colored the GP2-Glycoprotein-plasma membrane shades of green. The model can be printed in a variety of materials and sizes.

3D Print Ebola Virus Ectodomain

[wps_products titles="Ebola Virus Ectodomain"]