Archive | 3D Printed

Humalog Insulin Hexamer

Humalog Insulin Hexamer

This is a model of the pharmaceutical drug Humalog, insulin lispro, in its stable macro-molecule hexamer form. It is colored by the protein’s bFactor, or atomic temperature. Chains A and C are stained yellow, and Chains B and D are stained dark orange-red. The core of the macromolecule shows the stable, cool binding region of each monomer, an […]

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3D print of Tresiba Insulin Hexomer

Tresiba Insulin Hexomer

This is a model of the pharmaceutical drug Tresiba, insulin degludec, in its stable macro-molecule hexamer form. Tresiba is a fascinating drug, engineered to create long, marcro-molecular filaments that get stored in fat. Attached to each hexamer are 6 hydrocarbon chains (blue-cyan sticks). They act like tails reaching out to a neighbor hexamer to bind. […]

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3D Print of Novolog Insulin Hexomer

Novolog Insulin Hexomer

This is a model of the pharmaceutical drug Novolog, insulin aspart, in its stable macro-molecule hexamer form. It is colored by the protein’s bFactor, or atomic temperature. Chains A and C are stained yellow, and Chains B and D are stained dark orange-red. The core of the macromolecule shows the stable, cool binding region of each monomer, an […]

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3D Print of Human Insulin Hexomer

Human Insulin Hexamer

This is a model of human insulin in its stable macro-molecule hexamer form. It is colored by the protein’s bFactor or atomic temperature. Chains A and C are stained yellow, and Chains B and D are stained lite orange. The core of the macromolecule shows the stable, cool binding region of each monomer, an important characteristic […]

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3D Print of CRISPR Cas9

CRISPR Cas9 bound to Guide RNA and Target DNA

CRISPR Cas9 printed in full-color sandstone colored purple according to the protein’s bFactor, it’s propensity for movement. RNA is colored red, DNA colored Yellow and Green. Protein Descrption “The RNA-guided DNA endonuclease CRISPR Cas9 cleaves double-stranded DNA targets with a protospacer adjacent motif (PAM) and complementarity to the guide RNA. Recently, we harnessed Staphylococcus aureus […]

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Pembrolizumab, PD1, Keytruda, Biologic Models

Pembrolizumab bound to PD1

3D print of Pembrolizumab (KEYTRUDA) bound to PD-1. Model available in multiple materials and sizes. “Pembrolizumab (formerly MK-3475and lambrolizumab, trade name Keytruda)[1] is a humanized antibodyused in cancer immunotherapy. It destroys a protective mechanism on cancer cells, and allows the immune system to destroy those cancer cells. It targets the programmed cell death 1(PD-1) receptor. The drug was initially used in treating metastatic melanoma.” Protein […]

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CRISPR Cpf1, Biologic Models,

CRISPR Cpf1 bound to Guide RNA and Target DNA

Model Description This is a volumetric reconstruction of genome editing system, CRISPR Cpf1. It can be 3D printed in a variety of materials and sizes. Protein Description “Clustered Regularly Interspaced Short Palindromic Repeats from Prevotella and Francisella CRISPR/Cpf1 is a DNA-editing technology analogous to the CRISPR Cas9 system, characterized in 2015 by Feng Zhang‘s group from the Broad Institute and MIT. […]

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pembrolizumab_3Dprint

Comparative Analysis Pembrolizumab and PD-1 Receptor Binding Properties

Immunotherapy is the treatment of cancer using antibodies that target points of failure in the life cycle of cancer cells. Many of these therapies involve altering monoclonal antibodies to target specific proteins associated to different types of cancer. Understanding the binding properties of these proteins is of utmost importance. Pembrolizumab, an igG4 Monoclonal Antibody Pembrolizumab […]

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