Use this 3D printed protein model of the HbA1c, the protein marker that helps identify diabetes onset and tested for in the HbA1c (“A1c”) blood test. Use this 3D model to explain the dangers of high blood sugar or a reminder to monitor your blood sugar. Model available in multiple sizes and material finishes!
Glycated Hemoglobin (HbA1c) is a derivative compound that results when Hemoglobin (Hb) is exposed to high levels of blood sugar for prolonged periods of time. Sugar is extremely cytotoxic and readily binds to proteins throughout the body. Protein glycation causes structural changes to occur in the protein, preventing it from achieving ideal 3D configurations
This is a 3D print of Glycated Hemoglobin (HbA1c), created from PDB ID: 3B75. The globulin chains (2x A,B) of this model are colored white, HEME groups red, and Oxygen Molecules Blue. This model also visualizes the HbA1c diabetes blood test by showing how sugar molecules (cyan) attach to proteins changing their shape and decrease its functionality. Based on simulations of potential glycation sites, we have isolated the Lys binding residues (medium Grey) and attached sugar molecules. When compared to our normal Oxygenated Hemoglobin (Hb), you can quickly explain both what the HbA1c blood test examines, as well as why it is so important for patients to control their blood glucose.
3D Print Glycated Hemoglobin A1c
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Glycated Hemoglobin A1c and Diabetes Youth Camps
Shortly after completing the design and fabrication of the Hemoglobin A1c Teaching Model, we tested the effectiveness of using it to teach children living with type 1 and 2 diabetes about the HbA1c test. The goal of the experiment was to explain to children the importance of checking their blood glucose regularly, explain what the HbA1c blood test analyses, and how prolonged exposure to glucose causes high HbA1c scores. We contacted the Diabetes Youth Foundation of Indiana to see if they’d like to try using our model during their yearly summer camp retreat.
Four age groups of children were introduced to the model during their discussion about the HbA1c test. The kid’s diabetes educator used the magnetized pieces of glucose (blue) to show how sugar binds to proteins. To represent increased HbA1c scores, the educator would attach more glucose pieces to the model. By demonstrating the action of protein glycation, she was able to relay complex information about the dangers of glucose while also reinforcing positive self-management practices like checking blood sugars regularly. After the class, the children were asked to answer a few questions about the A1c test and the information they learned while playing with the model. The results were more than fantastic. The diabetes educator reported that every single child took away new information about the test and the importance of good blood glucose control.
About Hemoglobin Proteins
Hemoglobin the most abundant protein inside red blood cells. But this isn’t the only place we find Hemoglobin. Various forms of Hemoglobin can be found through the body performing alternative functions similar to oxygen transport, like oxygen storage or protection from oxidation.
3D Print Oxygenated Hemoglobin Hb