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3D Print of Insulin Receptor bound by Insulin

Insulin Receptor, Biologic Models, Diabetes,

This is a 3D printed model of an Insulin Receptor bound by Insulin. Insulin Receptor printed in full-color sandstone. Receptor dimer chains colored blue and green. Insulin chains A and B colored Orange and Yellow). Prints are available in multiple sizes. Contact us for customization requests:

Protein Description

“Insulin receptor signaling has a central role in mammalian biology, regulating cellular metabolism, growth, division, differentiation, and survival. Insulin resistance contributes to the pathogenesis of type 2 diabetes mellitus and the onset of Alzheimer’s disease; aberrant signaling occurs in diverse cancers, exacerbated by cross-talk with the homologous type 1 insulin-like growth factor receptor (IGF1R). Despite more than three decades of investigation, the three-dimensional structure of the insulin-insulin receptor complex has proved elusive, confounded by the complexity of producing the receptor protein. Here we present the first view, to our knowledge, of the interaction of insulin with its primary binding site on the insulin receptor, on the basis of four crystal structures of insulin bound to truncated insulin receptor constructs. The direct interaction of insulin with the first leucine-rich-repeat domain (L1) of the insulin receptor is seen to be sparse, the hormone instead engaging the insulin receptor carboxy-terminal ?-chain (?CT) segment, which is itself remodeled on the face of L1 upon insulin binding. Contact between insulin and L1 is restricted to insulin B-chain residues. The ?CT segment displaces the B-chain C-terminal ?-strand away from the hormone core, revealing the mechanism of a long-proposed conformational switch in insulin upon receptor engagement. This mode of hormone-receptor recognition is novel within the broader family of receptor tyrosine kinases. We support these findings by photo-crosslinking data that place the suggested interactions into the context of the holoreceptor and by isothermal titration calorimetry data that dissect the hormone-insulin receptor interface. Together, our findings provide an explanation for a wealth of biochemical data from the insulin receptor and IGF1R systems relevant to the design of therapeutic insulin analogs. ”
PDB ID: 5KQV

Media Gallery

Insulin Receptor bound by Insulin
Insulin Receptor bound by Insulin
Insulin Receptor bound by Insulin
Insulin Receptor bound by Insulin
Insulin Receptor bound by Insulin
Insulin Receptor bound by Insulin
Insulin Receptor bound by Insulin
Insulin Receptor bound by Insulin
Insulin Receptor bound by Insulin
Insulin Receptor bound by Insulin
Insulin Receptor, Biologic Models, Diabetes
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Models available in multiple sizes. If you are an international customer or an educator with a .edu email address, purchase this Biologic Model directly from our printing service to reduce shipping costs or received an educator discount.

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