3D printed protein models of a FAB Antibody bound to Meningococcal fHbp. These models are designed to pair with the academic publication, Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp. (LINK )
Factor H binding protein (fHbp) is a lipoprotein of Neisseria meningitidis important for the survival of bacteria in human blood. fHpb is a component of two recently licensed vaccines against serogroup B meningococcus. In this crystal structure, we see a new approach using engineered human antibody to target fHbp.
The chains of these protein models are colored yellow and green for the antibody FAB fragments, and cyan and light blue for the fHbp. The chains of each protein are colored to enhance understanding of the protein structure by coloring the alpha helices, beta sheets and colors decreasing intensities of color saturation. To highlight the binding residues found in the research publication, we have colored each amino acid by atom type.