Happy Holidays from Biologic Discovery! 3D Print of a CENP-A-histone H4 complex bound to the Holiday Junction.
The crystal structure of an HJURP-CENP-A-histone H4 complex shows that HJURP binds a CENP-A-H4 heterodimer. The C-terminal ?-sheet domain of Holiday Junction caps the DNA-binding region of the histone heterodimer, preventing it from spontaneous association with DNA
Protein visualized by ribbon backbone with the Holiday Junction helices colored red and beta sheets colored cyan, active sites that bind DNA colored by atom type.
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