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PIP4K2A, Lewis Cantley, Biologic Models

3D Print of PIP4K II Alpha

$39.48$857.49 $39.48$837.49

This is a 3D print of PIP4K II Alpha created from an unpublished protein data set. This model is colored by atom type showing blue nitrogen and red oxygen atoms. All other atoms are colored white. These models are printed in full-color sandstone available in multiple sizes. Models are printed to order, please allow for two week for printing and shipping.

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Product Description

Protein Description

Phosphatidylinositol 4-kinase 2-alpha (PI4K2A) is the most abundant phosphatidylinositol 4-kinase in human cells and is responsible for the synthesis of approximately 50% of the total PI4P within the cell. PI4K2A is associated mainly with the membranes of the trans-Golgi network and early and late endosomes; its membrane association is achieved by a heavy palmitoylation within a specific cysteine-rich motif. Besides the synthesis of phosphatidylinositol 4,5-bisphosphate, PI4K2A is involved in various cellular processes including membrane trafficking, regulation of endosomal sorting promoting target protein recruitment to endosomes or trans-Golgi network, or signal transduction. Particularly, it regulates e.g. targeting of clathrin adaptor complexes to the Golgi apparatus, the Wnt signaling, or EGFR signaling pathway.

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