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Insulin Receptor, Biologic Models, Diabetes,
Insulin Receptor, Biologic Models, Diabetes

Insulin Receptor bound by Insulin

$100.36$1,681.78 $91.36$1,619.99

This is a This model is generated from PDB IDs:  3Wi4 and 2MFR. It is color-coded to denote the dimer configuration on the plasma membrane. Made to order, printed and shipped directly to you. ~2 weeks plus shipping.

For customers outside of the US, please visit our shapeways.com store to purchase and ship the same models directly to you

https://www.shapeways.com/shops/biologicmodels

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Product Description

Model Description

This is a 3D printed model of an Insulin Receptor bound by Insulin. Insulin Receptor printed in full-color sandstone. Receptor dimer chains colored blue and green. Insulin chains A and B colored Orange and Yellow). Prints are available in multiple sizes. Contact us for customization requests:

Protein Description

“Insulin receptor signalling has a central role in mammalian biology, regulating cellular metabolism, growth, division, differentiation and survival. Insulin resistance contributes to the pathogenesis of type 2 diabetes mellitus and the onset of Alzheimer’s disease; aberrant signalling occurs in diverse cancers, exacerbated by cross-talk with the homologous type 1 insulin-like growth factor receptor (IGF1R). Despite more than three decades of investigation, the three-dimensional structure of the insulin-insulin receptor complex has proved elusive, confounded by the complexity of producing the receptor protein. Here we present the first view, to our knowledge, of the interaction of insulin with its primary binding site on the insulin receptor, on the basis of four crystal structures of insulin bound to truncated insulin receptor constructs. The direct interaction of insulin with the first leucine-rich-repeat domain (L1) of insulin receptor is seen to be sparse, the hormone instead engaging the insulin receptor carboxy-terminal ?-chain (?CT) segment, which is itself remodelled on the face of L1 upon insulin binding. Contact between insulin and L1 is restricted to insulin B-chain residues. The ?CT segment displaces the B-chain C-terminal ?-strand away from the hormone core, revealing the mechanism of a long-proposed conformational switch in insulin upon receptor engagement. This mode of hormone-receptor recognition is novel within the broader family of receptor tyrosine kinases. We support these findings by photo-crosslinking data that place the suggested interactions into the context of the holoreceptor and by isothermal titration calorimetry data that dissect the hormone-insulin receptor interface. Together, our findings provide an explanation for a wealth of biochemical data from the insulin receptor and IGF1R systems relevant to the design of therapeutic insulin analogues. ”

http://www.rcsb.org/pdb/explore/explore.do?structureId=5KQV

Insulin Receptor 3D Molecular Animation

Model Gallery

Multiple sizes available, please visit our shapeways.com store for more options

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