• 3D Print of Human Insulin Hexomer

    Human Insulin Hexamer

    This is a model of human insulin in its stable macro-molecule hexamer form. It is colored by the protein’s bFactor or atomic temperature. Chains A and C are stained yellow, and Chains B and D are stained lite orange. The core of the macromolecule shows the stable, cool binding region of each monomer, an important characteristic […]

Niemann Pick Type C, Biologic Models

Niemann Pick

Protein Description Niemann-Pick C1 protein (NPC1) is a late-endosomal membrane protein involved in trafficking of LDL-derived cholesterol, Niemann-Pick disease type C, and Ebola virus infection. NPC1 contains 13 transmembrane segments (TMs), five of which are thought to represent a “sterol-sensing domain” (SSD). Although present also in other key regulatory proteins of cholesterol biosynthesis, uptake, and […]

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Pembrolizumab, Keytruda, PD1, biologic models,

Comparative Analysis of Pembrolizumab and PD-1 Receptor Binding Properties

Immunotherapy is the treatment of cancer using antibodies that target points of failure in the life cycle of cancer cells. Many of these therapies involve altering monoclonal antibodies to target specific proteins associated to different types of cancer. Understanding the binding properties of these proteins is of utmost importance. Pembrolizumab, an igG4 Monoclonal Antibody Pembrolizumab […]

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PI3K, Biologic Models,

Phosphoinositide 3-Kinase (PI3K)

3D Print of Phosphoinositide 3-Kinase (PI3K) denoting common mutation sites (E545, H1047) that result in an oncogenic enzyme. This model was created from PDB dataset: 5DXT and visualizes the PI3K inhibitor GDC-0326. Protein Description PI3K are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in […]

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PARP1, Zejula, Tesaro, Biologic Models, Protein Model, 3d printed molecule

PARP1 bound by Zejula

This is a visualization of PARP1 bound by Zejula, the first in class drug for women with recurrent ovarian cancer, regardless of BRCA mutation. Zejula is an oral medication taken once daily. Protein Description Poly(ADP-ribose) polymerase 1 (PARP1) is an enzyme that in humans is encoded by the PARP1 gene. It is one of the PARP family of enzymes. PARP1 […]

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MRI reconstruction, trial exhibits, medical malpractice, biologic animation

Trial Room Exhibits

Trial Room Exhibits Occasionally, attorneys will contact me and request media to be used in trials or witness depositions. Attorneys understand that medical procedures and personal injuries are difficult to explain verbally. Testimony relies on verbal explanations of things that require knowledge that most jurors simply don’t have. They often request 3D animations to simplify how trauma […]

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HbA1c, Hemoglobin A1c, Biologic Models

Hemoglobin A1c Molecular Model Kit

Hemoglobin A1c Blood Test The Hemoglobin A1c (HbA1c) blood test is given to nearly every single person living with diabetes and anyone at risk of developing diabetes. It is the preferred diagnostic tool used around the world to measure a patient’s long-term self-management of diabetes. Hundreds of millions of people each year will receive this test. Yet, despite […]

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Humalog Insulin Hexamer

Humalog Insulin Hexamer

This is a model of the pharmaceutical drug Humalog, insulin lispro, in its stable macro-molecule hexamer form. It is colored by the protein’s bFactor, or atomic temperature. Chains A and C are stained yellow, and Chains B and D are stained dark orange-red. The core of the macromolecule shows the stable, cool binding region of each monomer, an […]

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3D print of Tresiba Insulin Hexomer

Tresiba Insulin Hexomer

This is a model of the pharmaceutical drug Tresiba, insulin degludec, in its stable macro-molecule hexamer form. Tresiba is a fascinating drug, engineered to create long, marcro-molecular filaments that get stored in fat. Attached to each hexamer are 6 hydrocarbon chains (blue-cyan sticks). They act like tails reaching out to a neighbor hexamer to bind. […]

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3D Print of Novolog Insulin Hexomer

Novolog Insulin Hexomer

This is a model of the pharmaceutical drug Novolog, insulin aspart, in its stable macro-molecule hexamer form. It is colored by the protein’s bFactor, or atomic temperature. Chains A and C are stained yellow, and Chains B and D are stained dark orange-red. The core of the macromolecule shows the stable, cool binding region of each monomer, an […]

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