Archive | Proteins

shigaToxin_fullcolorSandstone

Shiga Toxin

Shiga toxins are a family of related toxins with two major groups, Stx1 and Stx2, expressed by genes considered to be part of the genome of lambdoid prophages.[1] The toxins are named for Kiyoshi Shiga, who first described the bacterial origin of dysentery caused by Shigella dysenteriae.   As the name suggests, this little bugger causes pretty bad dysentery in humans. Shiga-like Toxin is made of […]

Continue Reading
MT-3724, Molecular Templates, Biologic Models,

MT-3724 3D Macromolecule

MT-3724 is a new to immunotherapy from Molecular Templates, currently under investigation for the treatment of non-Hodgkin’s Lymphoma. This immunotoxin is based on Molecular Templates’ Engineered Toxic Bodies (ETBs) drug delivery platform and harnesses the immunotherapy power of receptor-specific targeting. MT-3724 demonstrates a unique mechanism of action, packing a cytotoxic 1-2-3 cancer killing punch. MT-3724’s Mechanism […]

Continue Reading 0
LptB2FG

3D Print of LptB2FG

This is a 3d print of LptB2FG, a transmembrane protein known to transport lipopolysaccharides (LPS) across the inner plasma membrane to the outer of bacteria. The presence of LPS inhibits the permeability of hydrophobic antibiotics and allows them to survive in harsh environments. Study of Lpt molecules is important to not only understand how LPS is […]

Continue Reading 0
Niemann, Pick C1, Ebola, LDL, Biologic Models

3D Print of Niemann Pick C1

This 3D print of Niemann-Pick C1 is printed in full-color sandstone and colored by the protein’s hydrophobicity. Blue is are the hydrophilic regions of the protein, and red colors the hydrophobic regions. Since this is a membrane bound protein, visualizing its hydrophobicity allows us to visually identify the hydrophobic portion that spans the plasma membrane.  Models are […]

Continue Reading 0
Pembrolizumab, Keytruda, PD1, biologic models,

Comparative Analysis of Pembrolizumab and PD-1 Receptor Binding Properties

Immunotherapy is the treatment of cancer using antibodies that target points of failure in the life cycle of cancer cells. Many of these therapies involve altering monoclonal antibodies to target specific proteins associated with different types of cancer. Understanding the binding properties of these proteins is of utmost importance. Pembrolizumab, an igG4 Monoclonal Antibody Some […]

Continue Reading 0
PI3K, Biologic Models,

Phosphoinositide 3-Kinase (PI3K)

3D Print of Phosphoinositide 3-Kinase (PI3K) denoting common mutation sites (E545, H1047) that result in an oncogenic enzyme. This model was created from PDB dataset: 5DXT and visualizes the PI3K inhibitor GDC-0326. Protein Description PI3K are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in […]

Continue Reading 0
PARP1, Zejula, Tesaro, Biologic Models, Protein Model, 3d printed molecule

3D Print of PARP1 bound by Zejula

This is a 3D print of PARP1 bound by Zejula, the first in class drug for women with recurrent ovarian cancer, regardless of BRCA mutation. Zejula is an oral medication taken once daily. Protein Description Poly(ADP-ribose) polymerase 1 (PARP1) is an enzyme that in humans is encoded by the PARP1 gene. It is one of the PARP family of enzymes. […]

Continue Reading 0
HbA1c, Hemoglobin A1c, Biologic Models

Hemoglobin A1c Molecular Model Kit

Hemoglobin A1c Blood Test The Hemoglobin A1c (HbA1c) blood test is given to nearly every single person living with diabetes and anyone at risk of developing diabetes. It is the preferred diagnostic tool used around the world to measure a patient’s long-term self-management of diabetes. Hundreds of millions of people each year will receive this test. Yet, despite […]

Continue Reading 0