Archive | Proteins

3D Print of Apaf-1 Caspase-9 Holoenzyme

Model Description This is a 3D print of Apaf-1 activating Caspase-9, a key protein involved in apoptosis, or programmed cell death. This model is colored by individual protein chains, with Caspace-9 colored shades of blue and Apaf-1 colored shades of magenta. Protein Description Mammalian intrinsic apoptosis requires activation of the initiator caspase-9, which then cleaves and […]

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Neutral Ceramidase, Biologic Models, 4WGK

3D Print of Neutral Ceramidase

Model Description This is a 3D print of Neutral Ceramidase colored by the protein’s bFactor, or atomic temperature (blue cool, red hot). Models are available in multiple sizes. Protein Description Neutral ceramidase (nCDase) catalyzes conversion of the apoptosis-associated lipid ceramide to sphingosine, the precursor for the proliferative factor sphingosine-1-phosphate. As an enzyme regulating the balance […]

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Sphingosine Kinase 1, 3VZB

3D Print of Sphingosine kinase 1

Model Description This is a 3D print of Sphingosine Kinase 1, colored by the protein’s bFactor, or atomic temperature (blue cool, red hot). The model is available in multiple sizes. Protein Description Sphingosine kinase 1 (SphK1) is a lipid kinase that catalyzes the conversion of sphingosine to sphingosine-1-phosphate (S1P), which has been shown to play […]

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shigaToxin_fullcolorSandstone

Shiga Toxin

Shiga toxins are a family of related bacterial toxins first discovered by Kiyoshi Shiga while researching the origins of dysentary. Two major groups of this toxin are found in the Shigella dysenteriae and the shigatoxigenic serotypes of Escherichia coli bacteria, Stx1 and Stx2.   As the name suggests, this little bugger causes pretty bad dysentery in humans. Shiga-like Toxin is made of 6 primary chains, 5 […]

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MT-3724, Molecular Templates, Biologic Models,

MT-3724 3D Macromolecule

MT-3724 is a new to immunotherapy from Molecular Templates, currently under investigation for the treatment of non-Hodgkin’s Lymphoma. This immunotoxin is based on Molecular Templates’ Engineered Toxic Bodies (ETBs) drug delivery platform and harnesses the immunotherapy power of receptor-specific targeting. MT-3724 demonstrates a unique mechanism of action, packing a cytotoxic 1-2-3 cancer killing punch. MT-3724’s Mechanism […]

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LptB2FG

3D Print of LptB2FG

This is a 3d print of LptB2FG, a transmembrane protein known to transport lipopolysaccharides (LPS) across the inner plasma membrane to the outer of bacteria. The presence of LPS inhibits the permeability of hydrophobic antibiotics and allows them to survive in harsh environments. Study of Lpt molecules is important to not only understand how LPS is […]

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Niemann, Pick C1, Ebola, LDL, Biologic Models

3D Print of Niemann Pick C1

This 3D print of Niemann-Pick C1 is printed in full-color sandstone and colored by the protein’s hydrophobicity. Blue is are the hydrophilic regions of the protein, and red colors the hydrophobic regions. Since this is a membrane bound protein, visualizing its hydrophobicity allows us to visually identify the hydrophobic portion that spans the plasma membrane.  Models are […]

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Pembrolizumab, Keytruda, PD1, biologic models,

Comparative Analysis of Pembrolizumab and PD-1 Receptor Binding Properties

Immunotherapy is the treatment of cancer using antibodies that target points of failure in the life cycle of cancer cells. Many of these therapies involve altering monoclonal antibodies to target specific proteins associated with different types of cancer. Understanding the binding properties of these proteins is of utmost importance. Pembrolizumab, an igG4 Monoclonal Antibody Some […]

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