Archive | Oncology

MT-3724, Molecular Templates, Biologic Models,

MT-3724 3D Macromolecule

MT-3724 is a new to immunotherapy from Molecular Templates, currently under investigation for the treatment of non-Hodgkin’s Lymphoma. This immunotoxin is based on Molecular Templates’ Engineered Toxic Bodies (ETBs) drug delivery platform and harnesses the immunotherapy power of receptor-specific targeting. MT-3724 demonstrates a unique mechanism of action, packing a cytotoxic 1-2-3 cancer killing punch. MT-3724’s Mechanism […]

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Pembrolizumab, Keytruda, PD1, biologic models,

Comparative Analysis of Pembrolizumab and PD-1 Receptor Binding Properties

Immunotherapy is the treatment of cancer using antibodies that target points of failure in the life cycle of cancer cells. Many of these therapies involve altering monoclonal antibodies to target specific proteins associated with different types of cancer. Understanding the binding properties of these proteins is of utmost importance. Pembrolizumab, an igG4 Monoclonal Antibody Some […]

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PI3K, Biologic Models,

Phosphoinositide 3-Kinase (PI3K)

3D Print of Phosphoinositide 3-Kinase (PI3K) denoting common mutation sites (E545, H1047) that result in an oncogenic enzyme. This model was created from PDB dataset: 5DXT and visualizes the PI3K inhibitor GDC-0326. Protein Description PI3K are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in […]

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PARP1, Zejula, Tesaro, Biologic Models, Protein Model, 3d printed molecule

3D Print of PARP1 bound by Zejula

This is a 3D print of PARP1 bound by Zejula, the first in class drug for women with recurrent ovarian cancer, regardless of BRCA mutation. Zejula is an oral medication taken once daily. Protein Description Poly(ADP-ribose) polymerase 1 (PARP1) is an enzyme that in humans is encoded by the PARP1 gene. It is one of the PARP family of enzymes. […]

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Pembrolizumab, ( KEYTRUDA ), PD1, Keytruda, Biologic Models

3D Print of Pembrolizumab KEYTRUDA bound to PD1

This is a 3D print of Pembrolizumab KEYTRUDA bound to PD-1. Models available in multiple materials and sizes. Pembrolizumab (formerly MK-3475 and lambrolizumab, trade name Keytruda) is a humanized monoclonal antibody used in cancer immunotherapy. It removes a protective mechanism on cancer and allows the immune system to destroy those cancer cells. It does so by targeting the programmed cell death 1(PD-1) receptor. The drug was initially […]

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sandstone_egfr_inactivet_gloss1

Inactive EGFR Tyrosine Kinase

This is a 3D print of X-ray crystallography dataset 4HJO, the Crystal Structure of the Inactive EGFR Tyrosine Kinase Domain with Erlotinib. 4TRP Protein Description Epidermal growth factor receptor (EGFR) exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor α (TGFα) (note, a […]

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