Archive | Models

shigaToxin_fullcolorSandstone

Shiga Toxin

Shiga toxins are a family of related toxins with two major groups, Stx1 and Stx2, expressed by genes considered to be part of the genome of lambdoid prophages.[1] The toxins are named for Kiyoshi Shiga, who first described the bacterial origin of dysentery caused by Shigella dysenteriae.   As the name suggests, this little bugger causes pretty bad dysentery in humans. Shiga-like Toxin is made of […]

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Pembrolizumab, Keytruda, PD1, biologic models,

Comparative Analysis of Pembrolizumab and PD-1 Receptor Binding Properties

Immunotherapy is the treatment of cancer using antibodies that target points of failure in the life cycle of cancer cells. Many of these therapies involve altering monoclonal antibodies to target specific proteins associated with different types of cancer. Understanding the binding properties of these proteins is of utmost importance. Pembrolizumab, an igG4 Monoclonal Antibody Some […]

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PI3K, Biologic Models,

Phosphoinositide 3-Kinase (PI3K)

3D Print of Phosphoinositide 3-Kinase (PI3K) denoting common mutation sites (E545, H1047) that result in an oncogenic enzyme. This model was created from PDB dataset: 5DXT and visualizes the PI3K inhibitor GDC-0326. Protein Description PI3K are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in […]

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MRI reconstruction, trial exhibits, medical malpractice, biologic animation

Trial Room Exhibits

Trial Room Exhibits Occasionally, attorneys will contact me and request media to be used in trials or witness depositions. Attorneys understand that medical procedures and personal injuries are difficult to explain verbally. Testimony relies on verbal explanations of things that require knowledge that most jurors simply don’t have. They often request 3D animations to simplify how trauma […]

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3D print of Tresiba Insulin Hexomer

Tresiba Insulin Hexomer

This is a model of the pharmaceutical drug Tresiba, insulin degludec, in its stable macro-molecule hexamer form. Tresiba is a fascinating drug, engineered to create long, marcro-molecular filaments that get stored in fat. Attached to each hexamer are 6 hydrocarbon chains (blue-cyan sticks). They act like tails reaching out to a neighbor hexamer to bind. […]

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3D Print of Novolog Insulin Hexomer

Novolog Insulin Hexomer

This is a model of the pharmaceutical drug Novolog, insulin aspart, in its stable macro-molecule hexamer form. It is colored by the protein’s bFactor, or atomic temperature. Chains A and C are stained yellow, and Chains B and D are stained dark orange-red. The core of the macromolecule shows the stable, cool binding region of each monomer, an […]

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3D Print of CRISPR Cas9

CRISPR Cas9 3D Print

CRISPR Cas9 printed in full-color sandstone colored purple according to the protein’s bFactor, it’s propensity for movement. RNA is colored red, DNA colored Yellow and Green. Protein Description “The RNA-guided DNA endonuclease CRISPR Cas9 cleaves double-stranded DNA targets with a protospacer adjacent motif (PAM) and complementarity to the guide RNA. Recently, we harnessed Staphylococcus aureus […]

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Pembrolizumab, ( KEYTRUDA ), PD1, Keytruda, Biologic Models

3D Print of Pembrolizumab KEYTRUDA bound to PD1

This is a 3D print of Pembrolizumab KEYTRUDA bound to PD-1. Models available in multiple materials and sizes. Pembrolizumab (formerly MK-3475 and lambrolizumab, trade name Keytruda) is a humanized monoclonal antibody used in cancer immunotherapy. It removes a protective mechanism on cancer and allows the immune system to destroy those cancer cells. It does so by targeting the programmed cell death 1(PD-1) receptor. The drug was initially […]

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