Archive | Disease

3D Print of Apaf-1 Caspase-9 Holoenzyme

Model Description This is a 3D print of Apaf-1 activating Caspase-9, a key protein involved in apoptosis, or programmed cell death. This model is colored by individual protein chains, with Caspace-9 colored shades of blue and Apaf-1 colored shades of magenta. Protein Description Mammalian intrinsic apoptosis requires activation of the initiator caspase-9, which then cleaves and […]

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shigaToxin_fullcolorSandstone

Shiga Toxin

Shiga toxins are a family of related bacterial toxins first discovered by Kiyoshi Shiga while researching the origins of dysentary. Two major groups of this toxin are found in the Shigella dysenteriae and the shigatoxigenic serotypes of Escherichia coli bacteria, Stx1 and Stx2.   As the name suggests, this little bugger causes pretty bad dysentery in humans. Shiga-like Toxin is made of 6 primary chains, 5 […]

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Niemann, Pick C1, Ebola, LDL, Biologic Models

3D Print of Niemann Pick C1

This 3D print of Niemann-Pick C1 is printed in full-color sandstone and colored by the protein’s hydrophobicity. Blue is are the hydrophilic regions of the protein, and red colors the hydrophobic regions. Since this is a membrane bound protein, visualizing its hydrophobicity allows us to visually identify the hydrophobic portion that spans the plasma membrane.  Models are […]

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Pembrolizumab, Keytruda, PD1, biologic models,

Comparative Analysis of Pembrolizumab and PD-1 Receptor Binding Properties

Immunotherapy is the treatment of cancer using antibodies that target points of failure in the life cycle of cancer cells. Many of these therapies involve altering monoclonal antibodies to target specific proteins associated with different types of cancer. Understanding the binding properties of these proteins is of utmost importance. Pembrolizumab, an igG4 Monoclonal Antibody Some […]

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PI3K, Biologic Models,

Phosphoinositide 3-Kinase (PI3K)

3D Print of Phosphoinositide 3-Kinase (PI3K) denoting common mutation sites (E545, H1047) that result in an oncogenic enzyme. This model was created from PDB dataset: 5DXT and visualizes the PI3K inhibitor GDC-0326. Protein Description PI3K are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in […]

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3D print of Tresiba Insulin Hexomer

3D Print of Tresiba Insulin Hexomer

This is a model of the pharmaceutical drug Tresiba, insulin degludec, in its stable macro-molecule hexamer form. Tresiba is a fascinating drug, engineered to create long, marcro-molecular filaments that get stored in fat. Attached to each hexamer are 6 hydrocarbon chains (blue-cyan sticks). They act like tails reaching out to a neighbor hexamer to bind. […]

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3D Print of Novolog Insulin Hexomer

3D Print of Novolog Insulin Hexomer

This is a model of the pharmaceutical drug Novolog, insulin aspart, in its stable macro-molecule hexamer form. It is colored by the protein’s bFactor, or atomic temperature. Chains A and C are stained yellow, and Chains B and D are stained dark orange-red. The core of the macromolecule shows the stable, cool binding region of each monomer, an […]

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