Shiga toxins are a family of related toxins with two major groups, Stx1 and Stx2, expressed by genes considered to be part of the genome of lambdoid prophages. The toxins are named for Kiyoshi Shiga, who first described the bacterial origin of dysentery caused by Shigella dysenteriae. As the name suggests, this little bugger causes pretty bad dysentery in humans. Shiga-like Toxin is made of […]
This is a 3d print of LptB2FG, a transmembrane protein known to transport lipopolysaccharides (LPS) across the inner plasma membrane to the outer of bacteria. The presence of LPS inhibits the permeability of hydrophobic antibiotics and allows them to survive in harsh environments. Study of Lpt molecules is important to not only understand how LPS is […]
This is a photo from a recent conference where our models were used to explain how different companies are using CRISPR in agriculture. Explore CRISPR Find out more about CRISPR by exploring different CRISPR projects we’ve created.
Download the free CRISPR Cpf1 Augmented Reality App and explore the protein’s internal atomic structure. Launch the Biologic Explorer and point your phone at this QR Code to launch a digital model of CRISPR Cpf1. Toggle on and off different structures to reveal the hidden beauty of x-ray crystallography data. Download the CRISPR Cpf1 Augmented Reality […]
This 3D print of Niemann-Pick C1 is printed in full-color sandstone and colored by the protein’s hydrophobicity. Blue is are the hydrophilic regions of the protein, and red colors the hydrophobic regions. Since this is a membrane bound protein, visualizing its hydrophobicity allows us to visually identify the hydrophobic portion that spans the plasma membrane. Models are […]
Immunotherapy is the treatment of cancer using antibodies that target points of failure in the life cycle of cancer cells. Many of these therapies involve altering monoclonal antibodies to target specific proteins associated with different types of cancer. Understanding the binding properties of these proteins is of utmost importance. Pembrolizumab, an igG4 Monoclonal Antibody Some […]
3D Print of Phosphoinositide 3-Kinase (PI3K) denoting common mutation sites (E545, H1047) that result in an oncogenic enzyme. This model was created from PDB dataset: 5DXT and visualizes the PI3K inhibitor GDC-0326. Protein Description PI3K are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in […]
This is a 3D print of PARP1 bound by Zejula, the first in class drug for women with recurrent ovarian cancer, regardless of BRCA mutation. Zejula is an oral medication taken once daily. Protein Description Poly(ADP-ribose) polymerase 1 (PARP1) is an enzyme that in humans is encoded by the PARP1 gene. It is one of the PARP family of enzymes. […]
There is no excerpt because this is a protected post.
This is a model of the pharmaceutical drug Humalog, insulin lispro, in its stable macro-molecule hexamer form. It is colored by the protein’s bFactor, or atomic temperature. Chains A and C are stained yellow, and Chains B and D are stained dark orange-red. The core of the macromolecule shows the stable, cool binding region of each monomer, an […]