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Human Cytomegalovirus HCMV Glycoprotein B

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Human cytomegalovirus (HCMV) poses a significant threat to immunocompromised individuals and neonates infected in utero. Glycoprotein B (gB), the herpesvirus fusion protein, is a target for neutralizing antibodies and a vaccine candidate due to its indispensable role in infection. HCMV is the leading infectious cause of congenital abnormalities in the Western world including hearing loss.…

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CRISPR Cas13d in Complex with crRNA

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CRISPR Cas13d in Complex with crRNA CRISPR Cas13a is a newly discovered member of the Genome editing system making waves in the biotech community. Explore this 3D printed protein model of CRISPR Cas13d (tinted green) to examine how it uses RNA (red) to target and edit viral RNA (purple). Protein model created from PDB ID:…

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SARS-CoV1 Receptor Binding Domain 5X58

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The SARS-CoV1 Spike Glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. Biologic Models designed this 3D printed protein model of the SARS-CoV1 Receptor Binding Domain 5X58 to help research scientists and the general public better understand the binding properties of the Spike Glycoprotein and how it compares to other Coronavirus Spike Glycoproteins.…

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SARS-CoV-2 RNA Polymerase inhibited by Remdesivir

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The outbreak of a novel coronavirus (SARS-CoV-2) represents a pandemic threat that has been declared a public health emergency of international concern. The SARS-CoV-2 RNA Polymerase is a key target for antiviral therapy. The 3D printed structure of SARS-CoV-2 RNA Polymerase inhibited by Remdesivir should enable the rapid development and evaluation of medical countermeasures to address…

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Cannabinoid Receptor CB1 5TGZ

THC Cannabinoid Receptor Complex 5tgz 3d printed

Cannabinoid receptors are part of the endocannabinoid system, which is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory. This 3D print of THC Cannabinoid Receptor Complex 5TGZ is designed to visualize THC bound inside the receptor-binding pocket. (more…)

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Nucleosome 3C1B

Nucleosome, Biologic Models, 3C1B

A Nucleosome is the basic structural unit of DNA that assembles into a chromosome. Each nucleosome consists of a segment of DNA wound in sequence around eight histone protein cores. This structure is often compared to thread wrapped around a spool.  Use this 3D printed model Nucleosome 3C1B showing how DNA wraps around a histone core to explain…

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RSV Postfusion Glycoprotein

RSV, Fusion, Glycoprotein, Prefusion, 3rrr

Deadly to newborn babies, the Human Respiratory Syncytial Virus (HSV) is a major cause of lower respiratory tract infection. Dynamic structural changes in the Fusion F Glycoprotein reveal and hide binding sites, making targets of new therapies difficult to identify. Explore RSV Fusion F Glycoprotein-3RRR and learn more about its Postfusion 3D structure. (more…)

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Psilocybin bound to Serotonin Receptor

Psilocybin, 4ib4, Biologic Model, Molecular Model

Psilocybin bound to Serotonin Receptor Psilocybin, the active ingredient in psychoactive mushrooms, has provided the spiritual and cultural bedrock of many great civilizations. The Aztecs referred to teonanácatl, which translates as ‘divine mushroom’, and modern neuroscience has revealed how psilocybin interacts with serotonin receptors in the brain in order to produce a range of consciousness-altering…

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Human Cytomegalovirus

3D Print HCMV

The Human Cytomegalovirus (HCMV) is the leading cause of viral birth defects. HCMV Pentamer Complex is considered a key target candidate for vaccine therapies. How HCMV avoids humoral immunity is not clear. New research into the elusive virus reveals the surprising role of the host cell’s endoplasmic reticulum to aid viral infection. (more…)

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TDP-43 Wild Type and Mutant in Complex with DNA

TDP-43, ALS, Biologic Models

TDP-43 Wild Type and Mutant in Complex with DNA ALS is a fatal motor neuron disorder characterized pathologically by TAR DNA binding protein ( TDP-43 ). The function of TDP-43 is uncertain, and role in ALS remains speculative. Genome scanning reveals mutations associated to neural apoptosis. (more…)

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EGFR Mutant Tyrosine Kinase

EGFR, Mutant, Biologic Models

EGFR Mutant Tyrosine Kinase Mutations in EGFR lead to over-expression of proteins and different types of cancers as cells continually and proliferate. This 3D print of EGFR Tyrosine Kinase visualizes the mutations of key residues that lock the protein’s A-loop (orange) in its active conformation resulting in continued cellular proliferation. (more…)

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