Author Archive | admin

Pembrolizumab, PD1, Keytruda, Biologic Models

Pembrolizumab bound to PD1

3D print of Pembrolizumab (KEYTRUDA) bound to PD-1. Model available in multiple materials and sizes. “Pembrolizumab (formerly MK-3475and lambrolizumab, trade name Keytruda)[1] is a humanized antibodyused in cancer immunotherapy. It destroys a protective mechanism on cancer cells, and allows the immune system to destroy those cancer cells. It targets the programmed cell death 1(PD-1) receptor. The drug was initially used in treating metastatic melanoma.” Protein […]

Continue Reading
CRISPR Cpf1, Biologic Models,

CRISPR Cpf1 bound to Guide RNA and Target DNA

Model Description This is a volumetric reconstruction of genome editing system, CRISPR Cpf1. It can be 3D printed in a variety of materials and sizes. Protein Description Clustered Regularly Interspaced Short Palindromic Repeats from Prevotella and Francisella CRISPR/Cpf1 is a DNA-editing technology analogous to the CRISPR Cas9 system, characterized in 2015 by Feng Zhang‘s group from the Broad Institute and MIT. […]

Continue Reading
CRISPR, Cpf1, Biologic Models

Custom 3D Printed Protein Models

Commission a Biologic Model Work with a biomedical visualization scientist to translate any x-ray crystallography data-set into a hand-held model of that protein. We’ll uncover what makes each protein interesting and design a unique work of art, a scientific model that tells your unique story. Fill out this short survey, and we’ll process a quote for […]

Continue Reading
pembrolizumab_3Dprint

Comparative Analysis Pembrolizumab and PD-1 Receptor Binding Properties

Immunotherapy is the treatment of cancer using antibodies that target points of failure in the life cycle of cancer cells. Many of these therapies involve altering monoclonal antibodies to target specific proteins associated to different types of cancer. Understanding the binding properties of these proteins is of utmost importance. Pembrolizumab, an igG4 Monoclonal Antibody Pembrolizumab […]

Continue Reading
sandstone_egfr_inactivet_gloss1

Inactive EGFR Tyrosine Kinase

This is a 3D print of X-ray crystallography dataset 4HJO, the Crystal Structure of the Inactive EGFR Tyrosine Kinase Domain with Erlotinib. 4TRP Protein Description “Erlotinib and gefitinib, tyrosine kinase inhibitors used to block EGFR (epidermal growth factor receptor) signalling in cancer, are thought to bind only the active conformation of the EGFR-TKD (tyrosine kinase domain). Through […]

Continue Reading
Oxygenated Hemoglobin Hb

Packaging Oxygenated Hemoglobin

It’s Packaging Day at Biologic Models. We’re sending out the first shipment of Oxygenated Hemoglobin to our customer in Switzerland! Here they are, our first order for Hemoglobin!  Mike and I checked everything over, put the final polish on the bases, and boxed each unit up.  50 down, 50 more to go Very amazing working […]

Continue Reading
wired_1

Hemoglobin Gets Its Own Action Figure

Wired Magazine and Biologic Models Shortly after creating the first 3D print of Oxygenated Hemoglobin, Wired Magazine found our blog post and wanted to write a short article on it. By the time the article was ready for press, Michael Gulen and I had completed our prototype cast from silicon molds. Thanks again Rachel Swaby for […]

Continue Reading